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joint replacement

A robotic assistant for joint replacement surgery

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Are you one of the millions of silent sufferers living with chronic pain caused by arthritis or an injury to the hip or knee?

While conservative treatment options are the first line of treatment, some patients with severe disease may require hip or knee replacement surgery.

While we’re more used to human surgeons wielding the scalpel, nowadays, such surgery can be done with the help of robotic technology.

In Malaysia, over 300 patients have undergone robotic arm- assisted knee or hip replacement surgery since its introduction here in recent years.

Consultant orthopaedic, joint and arthroplasty surgeon Dr Chua Hwa Sen shares that the popularity of robotic arm-assisted knee and hip replacement surgeries is growing due to its ability to provide each patient with a surgical experience that is specifically tailored to the individual’s needs and anatomy.

With the new technology, he says surgeons are able to facilitate more accurate placement of implants, while being minimally invasive in cutting the patient.

This allows patients to experience less post-operative pain and recover faster.

He explains: “Treatment begins with CT-based 3D modelling to help surgeons view in detail each patient’s diseased anatomy prior to surgery to formulate a personalised surgical plan.

“Given that every joint is different – even more so for diseased joints, as the degree of severity varies greatly in different patients – the robot (along with pre-operative CT scans and 3D reconstruction) greatly helps surgeons plan accurately for each patient.

“The robot intraoperatively helps surgeons to seek the most ideal position and size of new joints for the patients, as well as accurately resect the bones and implant the new joints.”

Interest among the surgical community in this procedure is also increasing, with more and more surgeons showing interest in being trained for these procedures.

They merely assist

Dr Chua also assures that the robot is not doing the entire surgery and is merely assisting with the operation.

“People often think that surgeons sit back and relax when the surgery is being conducted by the robot.

“That is not true.

“The robot is a semi-active robot. Hence, the procedure is called robotic arm-assisted joint replacement.

“The surgeon is there every step of the way to expose the joints, release soft tissues, feed live movement of the joints to the robots intraoperatively to have wider combinations of data.”

He explains that the robot’s function during surgery is to enable surgeons to be precise in determining the best placement of implants within the joint.

The robot can accurately feed back data that is impossible to be detected with the naked eyes, he says, adding that it can adjust bone cuts and the degree of joint rotation as precisely as 0.1mm and 0.5 degrees respectively.

“Accuracy makes the surgery less invasive and enables us to sacrifice less healthy bone and tissues.

“‘The more we see, the more you keep’ is the key message of CT- based 3D modelling robotic arm-assisted joint replacement to our patients.”

Dr Chua notes that the robot’s accuracy reduces post-operative pain greatly, reduces the need for physical therapy, helps patients accept new joints with less effort, achieves a much better outcome, and potentially increases the longevity of the new implants.

Urging the public to be more open to technological advancements, he says the rise of robotics and artificial intelligence in healthcare is beneficial to society and should be embraced.

“Instead of being wary of it, let it assist us and improve our quality of life.”

Originally Appeared Here

Filed Under: joint replacement, ORTHO NEWS

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty

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Introduction

Although a substantial portion of the United States population has been infected with and recovered from Coronavirus Disease-19 (COVID-19), many patients may have persistent symptoms and complications from disease-driven respiratory disease, arrhythmias, and venous thromboembolism (VTE). With institutions resuming elective total joint arthroplasties (TJA), it is unclear whether a prior resolved diagnosis of COVID has any implications on postoperative outcomes.

Methods

All elective TJA performed in 2021 at our institution were retrospectively reviewed and a history of prior COVID+ result recorded. Baseline demographics, days from prior COVID+ result to surgery date, preoperative methicillin-resistant Staphylococcus aureus (MRSA) nares colonization, and laboratory markers were obtained to determine baseline characteristics. Postoperative estimated blood loss (EBL), length of stay (LOS), rate of revision surgery, and discharge destination were compared between groups. Perioperative and postoperative rates of VTE, urinary tract infection (UTI), pneumonia, postoperative oxygen supplementation, cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery were recorded.

Results

Of the 155 elective TJA performed in 2021, 24 patients had a prior COVID+ diagnosis with a mean of 253 days from positive result to surgery date. There were no significant differences in baseline demographics, comorbidities, and preoperative lab markers between groups. Surgeries on patients with a prior COVID+ had a significantly higher EBL (260 vs 175cc), but postoperative outcomes of VTE, UTI, pneumonia, oxygen supplementation requirement, nares MRSA+, cardiac disease, and infection rates between groups were similar. Bivariate logistic regression revealed increased days from COVID+ diagnosis (>6 months) to surgery date were associated with a shorter LOS.

Conclusion

Although a prior COVID+ diagnosis had increased intraoperative blood loss, there were no significant differences in respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA. This study suggests that asymptomatic C+ patients receiving elective TJA do not require more aggressive prophylactic anticoagulation or antibiotic regimens to prevent VTE or perioperative infections. As institutions around the nation resume pre-COVID rates of arthroplasty surgeries, a prior diagnosis of COVID appears to have no effects on postoperative complications.

Introduction

Due to the COVID-19 nonessential procedure restriction, there was a large decrease in orthopedic procedures during the pandemic. One study estimated that approximately 30,000 primary and 3000 revision hip and knee arthroplasty procedures were canceled each week throughout the COVID-19 nonessential procedure restrictions [1]. As cases resumed, multiple studies have explored the short-term effects of COVID-19 on the perioperative morbidity and mortality of various orthopedic surgeries. A 2020 study by Kayani et al. demonstrated an increased length of hospital stay, more critical care admissions, higher risk of perioperative complications, and increased mortality in COVID-19-positive (C+) patients undergoing hip fracture surgery compared to COVID-19-negative (C-) patients [2]. These results were consistent with other orthopedic surgical outcomes of femur neck and ankle fracture surgeries [3,4].

Several notable complications that were tightly bound to the COVID-19 virus were the increased risk of venous thromboembolism, atrial fibrillation, as well as respiratory issues inherent to the virus. As recently assessed by Forlenza et al., the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) was significantly higher in COVID-19 patients undergoing total joint arthroplasty (TJA), owing to the hypercoagulability associated with the inflammatory state [5]. Additionally, the study determined a temporal relationship between COVID-19 diagnosis and TJA, with an increased risk of DVT and PE in patients who were diagnosed with COVID-19 one month prior to their operation versus two or three months. This temporalizing trend was also witnessed when assessing the post-operative risk for pneumonia between C+ and C- patients [6,7]. Likewise, a study exploring the complication rates in C+ patients after hip fracture repair demonstrated an increased risk of post-operative atrial fibrillation compared to C- patients [7].

Notably, a rare yet significant complication of joint replacement is the risk of infection of the prosthesis which is a common cause of joint replacement revision. While minimal data has been presented regarding the risk of prosthetic joint infection, previous studies have demonstrated no significant risk of infection in TJA [6,8]. Additionally, the imposed restriction during the COVID-19 pandemic significantly hindered the ability of patients to seek adequate and continuous rehabilitation post-operatively which led to overall worse patient-reported outcomes [9]. Lastly, while the length of hospital stay (LOS) for surgical orthopedic patients has decreased in hopes of limiting the risk of COVID-19 infection, there was a significant increase in LOS in a previous study in C+ hip fracture patients compared to C- patients secondary to increased risk for complications as well as slower rehabilitation and dependence on oxygen supplementation.

While the short-term effects of a recent COVID-19 diagnosis on post-operative outcome have been explored, the effects of a previous C+ diagnosis and recovery on the outcomes of an orthopedic procedure and, more specifically, total joint arthroplasties, remains unclear. As the COVID-19 virus becomes increasingly more ubiquitous, it is important to gain an understanding regarding the complications or lack thereof that previously infected patients may face in future TJA procedures. For this reason, the objective of this study is to establish the complication risks of previous COVID-19-positivity on the postoperative outcomes of total joint arthroplasty.

This study aims to identify any significant differences in prosthetic joint infections, DVT and PE incidence, post-operative oxygen requirement, estimated blood loss (EBL), and LOS between prior asymptomatic C+ and C- patients undergoing TJA.

Materials & Methods

All elective TJA performed in 2021 at our institution were retrospectively reviewed and a history of prior PCR C+ result recorded. The study protocol was reviewed and approved by the University of California, Irvine Institutional Review Board. Baseline demographics, days from prior C+ result to the surgery date, preoperative methicillin-resistant Staphylococcus aureus (MRSA) nares colonization, and preoperative laboratory markers were obtained to determine baseline characteristics between groups.

All patients received standardized preoperative optimization including weight control and medical co-management when indicated. Within 72 hours prior to surgery, all asymptomatic patients received a COVID test to ensure no active infection or spread of infection through asymptomatic carriers. Patients with C+ results were rescheduled at least four weeks after the last C+ test and retested to ensure negative COVID test 72 hours prior to new surgical date. On the date of surgery, all patients were tested for MRSA Nares in the preoperative area. Patients were then prepped and draped in a standardized fashion including preoperative shaving with electrical clippers as needed and scrub with chlorhexidine gluconate for skin antisepsis. Preoperative prophylaxis included weight-based antibiotic dosing of Ancef, or Vancomycin and Gentamycin for those with penicillin allergies, or for those with a positive MRSA colonization. Of note, the approaches used for the hip procedure were entirely anterior approaches while the approach for knee arthroplasty was the medial parapatellar approach. Postoperatively, patients received two doses of cefazolin 2 grams for 24 hours per standard protocol. Post-surgical venous thromboembolism (VTE) chemoprophylaxis consisted of aspirin 81 mg twice daily for six weeks with the addition of Sequential Compression Devices (SCDs) or compression stockings for patients without any prior history of a DVT. Patients with a history of atrial fibrillation were resumed on their home oral anticoagulant (Apixaban or Rivaroxaban) on postoperative day 1 without aspirin. Patients who were unable to take home oral anticoagulant or aspirin were given daily Lovenox 40 mg injections for six weeks for VTE chemoprophylaxis.

Postoperative estimated blood loss (EBL), length of stay (LOS), rate of revision surgery, and discharge destination were compared between groups. Perioperative and postoperative rates of VTE, urinary tract infection (UTI), pneumonia, postoperative oxygen supplementation, new cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery were recorded. Patients who required any supplemental oxygenation, including nasal cannula or oxygen mask, and patients who required blood transfusion(s) were recorded. Periprosthetic joint infection (PJI) was determined using the updated 2018 criteria for periprosthetic infections including the presence of a sinus tract or two positive cultures with the same pathogen comprising the major criteria, and elevated C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), synovial WBC, Leukocyte esterase, alpha-defensin, synovial polymorphonuclear leukocyte (PMN), synovial CRP comprising minor criteria [10].

Analysis was performed using the SPSS Statistical Tool. Chi-squared tests were used to determine the relationship between prior COVID+ results with postoperative EBL, LOS, rate of revision surgery, discharge destination, rates of VTE, UTI, pneumonia, postoperative oxygen supplementation, cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery. Bivariate logistic regression analysis controlling for baseline demographics was used to determine the relationship between COVID+ diagnosis and association with postoperative complications. Additionally, days from prior C+ diagnosis to surgical date were compared between groups for effects on increased EBL and LOS. Multivariate linear regression was performed to identify COVID positivity as an independent risk factor for postoperative outcomes.

Results

Of the 155 elective TJA performed in 2021, 24 patients had a prior C+ diagnosis with a mean of 253 days from positive result to surgery date. Of note, the 155 TJA consisted of 93 (60%) knee and 62 (40%) hip arthroplasty. There were no significant differences in comorbidities, BMI, type of postoperative chemical VTE prophylaxis, and WBC/INR preoperative lab markers between groups (Table 1). Although C+ patients had a significantly higher preoperative Hb level, C+ patients were more likely to be males. There were no statistically significant differences with regard to performing surgeon, type of arthroplasty (hip or knee), ASA classification, and smoking status between the two groups.

Demographic Variable +COVID-19 (n = 24) -COVID-19 (n = 131) p
Age, mean ± SD 66.8 ± 9.5 68.0 ± 10.6 0.593
Sex <0.001
                  Male, n (%) 18 (75.0) 46 (35.1)
                  Female, n (%) 6 (25.0) 85 (64.9)
BMI, mean ± SD 31.9 ± 5.3 30.4 ± 7.0 0.315
Days From COVID-19+ To Surgery, mean ± SD 253.5 ± 189.3 — —
Diabetes, n (%) 9 (37.5) 40 (30.5) 0.485
Postoperative Blood Thinner 0.490
                   ASA, n (%) 21 (87.5) 110 (84.6)
                   Lovenox, n (%) 0 (0) 7 (5.4)
                  Xarelto/Eliquis, n (%) 3 (12.5) 10 (7.7)
                  Multiple, n (%) 0 (0) 3 (2.3)
Preoperative Nares MRSA+, n (%) 2 (8.3) 2 (1.5) 0.114
Preoperative Laboratory Values
                  WBC, mean ± SD 6.4 ± 1.8 7.3 ± 2.4 0.076
                  INR, mean ± SD 1.0 ± 0.1 1.1 ± 0.3 0.265
                  Hb, mean ± SD 14.0 ± 1.5 12.8 ± 2.1 0.006
Table
1: Demographics

BMI, body mass index; ASA, aspirin; MRSA, methicillin-resistance staphylococcus aureus; WBC, white blood cell; INR, international normalized ratio; Hb, hemoglobin

Surgeries on patients with a prior COVID+ had a significantly higher EBL (260 vs 175cc), but postoperative outcomes of VTE, UTI, pneumonia, oxygen supplementation requirement, nares MRSA+, cardiac disease, and infection rates between groups were similar (Tables 2, 3). Of note, no patients within the study required a blood transfusion. Bivariate logistic regression revealed increased days from COVID+ diagnosis (>6 months) to surgery date was associated with a shorter LOS (Table 4). Last, multivariate analysis (Table 5) demonstrated that prior COVID+ diagnosis was associated with greater EBL, and a COVID+ diagnosis cutoff of one year ago was also associated with significantly shorter LOS.

Postoperative Complication +COVID-19 (n = 24) -COVID-19 (n = 131) p
EBL (mL), mean ± SD 258.3 ± 124.8 175.4 ± 177.9 0.030
PE, n (%) 0 (0) 1 (0.8) 1.000
UTI, n (%) 0 (0) 5 (3.8) 1.000
Postoperative Bleeding or Hematoma, n (%) 0 (0) 5 (3.8) 1.000
Pneumonia, n (%) 0 (0) 1 (0.8) 1.000
Postoperative Nasal Cannula/Oxygen Requirement in Hospital, n (%) 4 (16.7) 7 (5.3) 0.069
Renal Failure, n (%) 0 (0) 3 (2.3) 1.000
Sepsis, n (%) 0 (0) 1 (0.8) 1.000
Cardiac Arrhythmia, n (%) 0 (0) 6 (4.6) 0.591
Periprosthetic Joint Infection, n (%) 0 (0) 4 (3.1) 1.000
Revision Joint Surgery, n (%) 1 (4.2) 3 (2.3) 0.493
Revision for Infection, n (%) 1 (4.2) 3 (2.3) 0.493
Length of Stay, mean ± SD 2.6 ± 1.2 2.5 ± 1.6 0.802
Discharge Destination 0.206
Home, n (%) 18 (75.0) 114 (87.0)
Rehabilitation, n (%) 6 (25.0) 17 (13.0)
Table
2: Postoperative Complications

EBL, estimated blood loss; PE, pulmonary embolism; UTI, urinary tract infection.

Postoperative Complication OR 95% CI p
PE 0.000 (0.000, 0.000) 0.998
UTI 0.000 (0.000, 0.000) 0.998
Postoperative Bleeding/Hematoma 0.000 (0.000, 0.000) 0.998
Pneumonia 0.000 (0.000, 0.000) 0.998
Postoperative Nasal Cannula/Oxygen Requirement in Hospital 3.543 (0.950, 13.211) 0.060
Renal Failure 0.000 (0.000, 0.000) 0.998
Sepsis 0.000 (0.000, 0.000) 0.998
Cardiac Arrhythmia 0.000 (0.000, 0.000) 0.998
Periprosthetic Joint Infection 0.000 (0.000, 0.000) 0.998
Revision Joint Surgery 1.855 (0.185, 18.620) 0.599
Revision for Infection 1.855 (0.185, 18.620) 0.599
Discharge to Rehabilitation 2.235 (0.778, 6.421) 0.135
Table
3: Bivariate Logistic Regression for COVID-19 Positivity and Postoperative Complications

PE, pulmonary embolism; UTI, urinary tract infection.

Postoperative Complication USC B 95% CI p
EBL
                COVID-19+ 82.913 (7.908, 157.919) 0.030
                Days From COVID-19+ To Surgery -0.170 (-0.451, 0.112) 0.225
                COVID-19+ Cutoff 3 Months -14.737 (-147.610, 118.136) 0.820
                COVID-19+ Cutoff 6 Months -28.571 (-137.427, 80.284) 0.592
                COVID-19+ Cutoff 1 Year -87.500 (-195.381, 20.381) 0.107
Length of Stay
                COVID-19+ 0.087 (-0.597, 0.772) 0.802
                Days From COVID-19+ To Surgery -0.003 (-0.006, -0.001) 0.006
                COVID-19+ Cutoff 3 Months -1.032 (-2.241, 0.178) 0.091
                COVID-19+ Cutoff 6 Months -1.229 (-2.144, -0.313) 0.011
                COVID-19+ Cutoff 1 Year -1.437 (-2.352, -0.523) 0.004
Table
4: Bivariate Linear Regression for COVID-19 Positivity and Postoperative Complications

Having a history of COVID positivity was associated with significantly greater EBL. As the number of days from COVID-19+ increases, the hospital length of stay decreases. If COVID-19 positivity >6 months or >1 year away from a current hospital stay, LOS significantly decreased.

EBL, estimated blood loss; USC B, unstandardized coefficient B.

Perioperative Variables USC B 95% CI p
EBL
              COVID-19+ 78.607 (9.328, 147.887) 0.027
              Age -1.344 (-3.713, 1.025) 0.263
              Female Sex -65.317 (-123.139, 7.495) 0.065
              BMI -2.137 (-6.476, 2.203) 0.331
              Diabetes -49.504 (-106.745, 7.736) 0.089
              ASA Perioperative Blood Thinner -72.002 (-141.647, 2.173) 0.076
              INR 0.346 (-108.647, 109.338) 0.995
              Hg -6.301 (-22.296, 9.695) 0.437
Length of Stay
             COVID-19+ Cutoff 1 Year -1.703 (-3.167, -0.240) 0.026
             Age 0.034 (-0.018, 0.086) 0.177
             Female Sex -0.041 (-1.514, 1.433) 0.953
             BMI 0.052 (-0.050, 0.155) 0.290
             Diabetes 0.171 (-1.439, 1.781) 0.822
             ASA Perioperative Blood Thinner -1.333 (-3.355, 0.689) 0.178
             INR -1.910 (-13.301, 9.480) 0.723
             Hg -0.316 (-0.878, 0.246) 0.246
Table
5: Multivariate Linear Regression for COVID-19 Positivity and Estimated Blood Loss

In a multivariate model, COVID-19 positivity was associated with much greater EBL while female sex and ASA use were preoperatively associated with decreased EBL. A COVID-19+ cut-off of 1 year ago was associated with significantly shorter LOS.

EBL, estimated blood loss; BMI, body mass index; ASA, aspirin; INR, international normalized ratio; Hg, hemoglobin; USC B, unstandardized coefficient B.

Discussion

As the number of TJA performed increases to pre-pandemic rates nationwide, the population of asymptomatic prior C+ patients receiving TJA will increase. Although prior studies have demonstrated higher rates of cardiopulmonary complications, thromboembolic disease, renal injury, and urinary tract infections in postoperative COVID+ patients one month from joint arthroplasty, our study focuses on whether a preoperative resolved asymptomatic COVID+ diagnosis increases the risks for complications and outcomes [6]. Preoperative risk stratification for elective TJA is an important component of perioperative planning and medical optimization in an effort to reduce healthcare costs and decrease preventable complications [11]. As institutions implement COVID testing protocols to prevent the active perioperative spread of COVID in TJA, it is still unknown whether asymptomatic patients have an increased hypercoagulable inflammatory state that may perhaps warrant a prolonged prophylactic course of antibiotics or chemical DVT prophylaxis not routinely prescribed [12]. In this study, we demonstrate preliminary results of a prior COVID+ diagnosis having no increased rates of respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA with the standard postoperative protocol.

While other studies focus on the effects of a new COVID diagnosis during the perioperative period, our study is the first to our knowledge to examine the effects of a prior asymptomatic PCR COVID+ diagnosis > at least 3 months prior to the surgical date. Our average COVID+ diagnosis of ~250 days prior to surgery is relevant for healthcare providers stratifying a rising number of asymptomatic COVID+ elderly patients who have never undergone stresses of surgery post COVID. There are conflicting studies reporting on the prolonged duration of increased DVT, cardiac abnormalities, and PE rates in COVID patients after inoculation, and our study aims to demonstrate asymptomatic patients, >6 months since the last positive PCR test, have no increased risks of UTI, PJI, PE, DVT, and cardiac arrhythmias after joint arthroplasty [13]. Many of our patients had delayed procedures due to positive testing, and they are at increased risk for thromboembolism due to worsened arthritis and reduced mobility during the self-isolation period [14]. Despite theories on increased coagulopathy in prior positive patients, our findings of no increased risks for thromboembolic disease suggest more aggressive prophylactic anticoagulation regimens may not be necessary and otherwise increase the risk for hematoma formation [6,15]. While many of our patients were limited in formal therapy sessions due to pandemic restrictions, our patients were given supplemental standardized home therapy programs to encourage active recovery and mobility.

Although effects of prior COVID diagnosis on respiratory complications have been seen in prior literature, there are no studies correlating PCR COVID diagnosis to either increased MRSA nares colonization or supplemental oxygen requirements in arthroplasty patients. MRSA nares colonization is a known risk factor for periprosthetic joint infections, and prior reports indicate increased MRSA colonization during the COVID pandemic [16]. Our study indicates prior PCR COVID diagnosis had no increased risk for MRSA colonization despite theories on the decreased nasal immune response to respiratory co-pathogens after COVID infection [17]. Our overall low MRSA nares rate may reflect institutionalized trends of mask-wearing, physical distancing, reducing crowds, and hand hygiene used to prevent the spread of respiratory infections. In fact, our COVID patients had no increased leukocytosis or risk for overall UTI, pneumonia, or PJI complications. Low infection rates suggest no overall compromise to the immune function combined with the possible efficacy of current social distancing trends. Our C+ patients not only had no increased rates of MRSA nares colonization and postoperative infections, but they had no increased rates of postoperative oxygen supplementation requirements during their inpatient stay and at physical therapy sessions. Preventing atelectasis is an important postoperative goal to reduce further postoperative hypoxemia that may lead to arrhythmias, myocardial ischemia, and cognitive dysfunction [18]. Prior COVID+ PCR had no effects on post ambulatory breathing oxygenation and no increased rates of nasal cannula use that would indicate reduced respiratory function.

While comorbidities between groups were similar, this study had a higher percentage of males who were COVID+ and subsequently preoperative Hb was higher in the C+ group due to the greater percentages of males [19]. C+ was a significant risk factor for increased EBL intraoperative, which may reflect C+ coagulopathy and loss of antithrombotic mechanisms from imbalances between coagulation and inflammation [12]. While there were no increased postoperative hematomas, INR levels, or postoperative blood transfusions seen in the C+ group, surgeons should strive to obtain meticulous hemostasis and be aware that C+ may increase surgical blood loss. Although discharge destination and LOS were similar between C+ and C-, hospital LOS was inversely related to the number of days from C+ diagnosis to surgical date. COVID-19 positivity >6 months or >1 year away from surgery significantly decreased overall LOS, which may suggest faster recovery and less need for inpatient monitoring. It is possible that our C+ patients with increased EBL combined with inflammatory post-surgical stresses experienced greater physiologic demand postoperatively that required longer inpatient recovery [20]. The findings from this study have important insight for future arthroplasty centers as the surgical community begins to recover from the Covid-19 pandemic, which has caused widespread and numerous delays in surgical care.

There are several limitations to this study. Despite our preliminary findings, suggesting that elective joint replacement surgery is safe in patients with a history of COVID-19, the study is not well powered to detect differences in in-hospital complications, especially for rarer complications such as pulmonary emboli. Additionally, more research is needed in larger samples to confirm the robustness of this finding, as well as to investigate longer-term outcomes. Our cohort of C+ patients may not represent the true spectrum of the disease of all prior C+ patients as our population undergoing elective joint replacement were medically cleared and self-selected to undergo TJA. It is possible that our C+ patients were on the healthier side of the COVID spectrum as sicker patients are more likely to not be medically optimized for elective surgery and be at higher risk of perioperative complications. Since a C+ diagnosis is not randomized and our findings reflect a retrospective review, our results must be viewed as associations and a larger sample size is needed to detect the possible variability in outcomes associated with the various increasing strains of COVID.

Conclusions

Although a prior COVID+ diagnosis had increased intraoperative blood loss, there were no significant differences in respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA. Increased time from C+ diagnosis to surgical date predicted less EBL and shorter LOS, which may reflect a possible improved recovery in C- compared to C+ patients. This study suggests that asymptomatic C+ patients receiving elective TJA do not require more aggressive prophylactic anticoagulation or antibiotic regimens to prevent VTE or perioperative infections. As institutions around the nation resume pre-COVID rates of arthroplasty surgeries, the effect of prior diagnosis of COVID should be further investigated across a larger sample size to determine the true effect of a prior diagnosis on overall outcomes.

Originally Appeared Here

Filed Under: joint replacement, ORTHO NEWS

Putting Your Best Foot Forward for Joint Surgery Success

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More than 1.25 million Americans will undergo knee or hip replacement surgery every year. And while most will report a dramatic improvement in their quality of life following recovery, some will experience a rougher road to recovery than others.

Joint replacement surgery can decrease pain and improve mobility. Patients can increase the success of the procedure by following expert advice during recovery.

If you or someone you care about is thinking about joint replacement surgery, experts say that there are steps you can take to make your recovery smoother and your procedure even more successful.

“The best thing for a good outcome after elective joint replacement surgery is to be informed and prepared,” says Dr. Elizabeth Desmond, orthopedic surgeon at Dignity Health Sierra Nevada Memorial Hospital. “It is important to have a good understanding and reasonable expectations of your operative and post-operative course.”

Dr. Desmond says the key is to ask questions early on in the process.

“You should ask how long you will be in the hospital (some joint replacements are done as an outpatient, others with a very short hospital stay),” she explains. “You should also have a discussion about pain management and you should have your home set up ahead of time for your needs, including having any needed assistive devices available.”

Dr. Desmond says patients should approach the pain management conversation with the goal of minimizing their use of opiate medications as much as possible. And regarding the home set up, she recommends minimizing stair use and planning ahead to ensure needed items are within each.

Recommended assistive devices may include a walker, a shower chair, a raised toilet seat, a bedside commode, or anything else your physician believes may be useful during your recovery.

Once your joint replacement surgery is complete and you’re back home, it’s important to remember that the work has only just begun. How you rehabilitate your joint will help to determine how your recovery goes and how successful your procedure ultimately is.

“The repeated goal at all stages is rehabilitation,” Dr. Desmond says. “The reason patients choose to have joint replacement is due to pain and a loss of function. The best way to ensure a good outcome is to participate in therapy/rehab and follow the specific activity restrictions and recommendations you have been given.”

While it may seem counterintuitive, Dr. Desmond says it is important to begin moving and walking as soon as possible after joint and hip replacement surgery.

“There will be some pain and discomfort, but delaying your rehab only makes recovery longer and more difficult,” she explains.

For the first couple days after surgery, Dr. Desmond says patients should focus on adequately controlling their pain (ideally a combination of non-narcotic and narcotic pain medications) and working with their physical therapist.

Then, one to two weeks following surgery, the focus should be on progressing with physical therapy rehabilitation.

“Do your assigned exercises as prescribed and wean off of narcotic pain medications,” Dr. Desmond says. “Ideally at this point you should stop taking narcotic pain medication if possible.”

One to two months out from surgery, the focus should continue to be strengthening the joint through rehabilitation with physical therapy.

“If you were given any specific activity or motion restrictions, these should be coming to an end at 6-8 weeks, which will make your rehab progress even better,” Dr. Desmond explains.

Throughout your recovery, you should keep an eye on your incision and the joint itself. Infections can happen and should be treated quickly.

The most common signs of infection are fevers, chills, night sweats, redness, increasing swelling, discharge or a foul smell around the wound.

Another complication that is infrequent but would need to be addressed quickly is a blood clot or pulmonary embolism, which may cause leg swelling, calf pain/cramping/soreness, shortness of breath, chest pain that worsens when you take a deep breath or cough, rapid breathing, or rapid pulse. Immediately contact your doctor if those symptoms are present.

In general, Dr. Desmond says patients should expect to be gradually improving following joint replacement surgery.

“There will be days that are worse than others, but the trajectory should be that of improvement,” she says. “Any changes that worsen and do not improve with rest or elevation should be reported and evaluated.”

If you are fortunate enough to have a spouse, family member of friend around to help you recover following joint surgery, they can help to increase the success of your procedure too.

“Having someone present is very important,” Dr. Desmond says. “The patient will need help with many basic tasks, from transportation, prescription pick up, changing dressings, food preparation, etc. The partner can help to ensure that the patient is taking all of the prescribed medications at the appropriate intervals and is aware of any signs of common complications.”

Finally, Dr. Desmond wants people to know that in general, joint replacement surgery is very successful in addressing issues of joint pain and decreased mobility.

“The important thing to remember is that the improvement will not happen all at once,” she says. “Most patients will take at least three months to return to their basic, daily, non-strenuous activities. Full recovery and strength can take up to six to 12 months. In the end, the vast majority of patients have a significant improvement in their quality of life.”

Originally Appeared Here

Filed Under: joint replacement, ORTHO NEWS

Robotics Procedure Helping People Recover From Joint Replacement Surgery

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Tulsa Bone and Joint’s Union Pines Surgery Center is now the first ambulatory surgery center in Oklahoma to have the Mako SmartRobotics technology.

With the Mako SmartRobotics system, surgeons can better see how surgeries like a knee replacement will impact the entire body.

“What the Mako allows us to do, the way I explain it to my patients, is it allows us to know the consequences of the bony cuts we’re going to make, before we actually make them,” said Dr. Scott Reid, an Orthopedic Surgeon.

This data can help surgeons decide the best course of action for each patient, because everyone does not react the same way.

This is especially helpful in situations where the result can be hard to predict.

“The problem with soft tissue releases is that they’re not very predictable,” said Reid. “You may think when you’re in the operating room that you’ve balanced the knee really well, ultimately that may not actually be the case.”

Finding potential problems earlier, can change the recovery process, and the lives, of patients.

“One outlier, if we have one patient out of 100 that has a poor outcome because we didn’t get the implants in exactly the way they needed to be, that’s a big burden to that patient and we want to try to eliminate those as much as possible,” said Reid. “But there’s a big cost to the system.”

Reid says this technology has been in hospitals for nearly a decade, but using the Mako at Tulsa Bone and Joint’s surgery center can benefit more patients.

“Now, I think we’ve got every insurance contract that we have, to include Medicare and all the other subsidiaries of Medicare, we have the technology available to them now,” said Reid.

He’s excited about the future of this technology and the number of people it can help in the future.

“If we can use this technology to provide a more consistent outcome to our patients, ultimately that’s what we’re looking for,” said Reid.

The first two knee replacements using this surgery were performed successfully last Thursday.


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Filed Under: joint replacement, ORTHO NEWS

Surgery for Juvenile Idiopathic Arthritis

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Most kids with juvenile idiopathic arthritis never need surgery, but if your child does, here’s what you can expect.

Some 300,000 children ages 16 or younger have juvenile idiopathic arthritis (JIA), an umbrella term for various health conditions that can cause joint pain, swelling, stiffness, and loss of motion. Like other forms of arthritis, JIA starts when a child’s immune system becomes overactive, triggering an inflammatory response.

It’s not uncommon for JIA to be a long-term health condition, but there are many effective medications that can treat your child’s arthritis. Thanks to these drugs, inflammation is often brought under control before it reaches the point of causing joint damage. That means kids diagnosed with JIA today are much less likely to need surgery than in generations past.

Medication, along with active treatment tools like exercise and assistive devices such as splints, mean that your child’s joint pain can often be kept to a minimum.

Still, though considered a last resort, surgery may sometimes benefit some of the most severe cases of JIA. This could be either because medication is unable to stop the progression of joint damage, or your child was not diagnosed with JIA until after joint damage had already occurred. In these cases, surgery may offer pain relief with JIA and could also restore function to damaged joints.

Who Needs Surgery for JIA?

Step one, say experts, is to try and avoid invasive procedures for JIA kids. “We try to treat children aggressively with medication so we can preserve their joints and avoid surgery,” says Farzana Nuruzzaman, M.D., a pediatric rheumatologist at Stony Brook Children’s Hospital and clinical assistant professor at the Renaissance School of Medicine at Stony Brook University in Stony Brook, NY. “Unfortunately, in some cases the arthritis has caused so much damage that certain types of surgery are needed.” In those cases, if your child is not improving on medication and her quality of life is suffering, surgery may be an option.

If your child’s jaw is affected by arthritis pain, for instance, surgery might be recommended, says Beth Susan Gottlieb, M.D., chief of the division of pediatric rheumatology at Northwell Health in New Hyde Park, NY. “Arthritis in the jaw can slow down the growth of the lower jaw, which causes a smaller jaw,” Dr. Gottlieb explains. “Surgery can improve the appearance of the face and make the joint healthier.”

Types of JIA Surgery

If your child is a candidate for JIA surgery, it helps to know what to expect. The surgical procedures that may be recommended include:

Osteotomy

In an osteotomy, explains Dr. Nuruzzaman, a bone is cut and repositioned to fix a bone deformity. Then the bone is reset into a better position. An osteotomy could be performed on the foot, hip, knee, or the temporomandibular joint (TMJ) in the jaw. Jaw surgery can not only make eating and chewing easier but can improve a child’s facial structure and self-confidence. This procedure is considered low-risk and safer than a total knee or hip replacement, according to the American College of Rheumatology.

Joint Fusion (Arthrodesis)

In a joint fusion, “the surgeon removes the damaged cartilage from the ends of two bones that form a joint and then holds [the bones] in place with a pin or a rod,” Dr. Nuruzzaman explains. Over time, the two bones fuse to form a single unit, much as a broken bone fuses when it heals. While arthrodesis can stabilize a joint and help it bear weight better, the fusion of these bones will result in the loss of some mobility. It’s usually performed on joints in the foot and ankle, hand and wrist, or spine, per the Arthritis Foundation.

Synovectomy

The synovium is a thin membrane that lines the joint capsule, but when JIA causes chronic inflammation of this lining, it grows much thicker and can affect the structure and function of the joint. In this procedure, explains Dr. Nuruzzaman, the surgeon removes inflamed synovial lining that develops from chronic inflammation.A synovectomy alsocan be done arthroscopically, says Daniel Lovell, M.D., professor of pediatrics at the University of Cincinnati School of Medicine at the Cincinnati Children’s Hospital Medical Center. “The surgeon can go in using a scope and can also do an injection of steroids at the same time, which can reduce pain,” he says.

Epiphysiodesis

This procedure can help correct a difference in leg lengths, Dr. Nuruzzaman explains. (Leg-length discrepancy is a common symptom of JIA, per the American Academy of Orthopeadic Surgeons). Epiphysiodesis is usually is for children whose anticipated leg-length discrepancy is nearly an inch and who have a year or two of growth remaining. In a temporary epiphysiodesis, metal plates may be used to temporarily halt bone growth in the longer leg. With a permanent epiphysiodesis, part of the growth plate is removed.

“The growth plate of the longer leg is removed or replaced with a metal plate so the longer leg growth stops,” Dr. Nuruzzaman says. In addition, Dr. Lovell explains, if a leg has excessive angulation due to arthritis causing one side of the knee to grow faster, then a temporary epiphysiodesis may be used to straighten the leg by limiting the growth on the faster growing side of the knee joint.

Total Joint Replacement (Arthroplasty)

An arthroplasty “is when the damaged joint is removed and replaced with an artificial joint,” Dr. Nuruzzaman says. Considered a last-ditch option for children, it is usually reserved for a joint that is so damaged, painful, and stiff that it interferes with a child’s quality of life and ability to function. The hip is the joint that is most commonly replaced, followed by the knee. “Total joint replacement is usually done in later adolescence or young adulthood,” says Dr. Lovell.

The Pros and Cons of Surgery for JIA

All surgeries have a potential risk, and the surgeon should carefully explain both risks and benefits. And keep in mind: surgery is generally not a cure. “Surgeries do not protect against the progression of the underlying inflammatory disorder,” Dr. Nuruzzaman says.

Moreover, some surgeries may need to be repeated. For instance, performing TMJ surgery before facial growth is complete (15 years for girls and 17 to 18 years for boys) may mean that repeat operations may be necessary.

One con of joint fusion is that after the surgery, your child will not be able to bend the joint. And sometimes, the bone does not fuse, the wound may not properly heal, or arthritis develops in nearby joints due to stress from the fusion. It is important that you and your child understand both the benefits and risks of joint fusion.

Another consideration: Artificial joints cannot grow like natural joints so if the joint is replaced before growth is complete, then the growth in the area of the replaced joint will stop. In addition, an artificial joint does not last forever. For this reason, repeat surgeries are typically needed and can be more challenging to perform.

The main benefit of surgery for JIA is that for many children with juvenile arthritis, surgery can offer pain relief and improve their quality of life.

What You Can Expect After Surgery

Recuperation from surgery for JIA varies depending on the surgery, the joint, your child’s overall health, and more. Full recovery from a joint fusion may take months. After an epiphysiodesis, the recovery is brief and has few complications, per the Arthritis Foundation. One possible complication is that the metal plates could loosen, or a leg that is corrected temporarily could revert to its previous length.

Osteotomy procedures are generally low risk, but recovery can be rough: The Arthritis Foundation notes that for a few months after the procedure, kids have to wear elastic bands to support the jaw. They may also need to use a palatal splint and eat a soft diet.

After a synovectomy, symptoms like pain and swelling should get better. Usually, though, the synovium will grow back over time if there is not control of the inflammation in the joint with the medicines used to treat the arthritis, Dr. Lovell says. The synovectomy can be repeated if this happens.

Outlook for Children with JIA

The good news is that JIA is treatable, most children who have it can expect to live normal lives, and very few will need joint surgery, Dr. Lovell says. Some children will see their JIA go into remission.

And surgery can be a good option for some children with JIA. “We try to avoid surgery,” says Dr. Nuruzzaman. “But in some cases, it can improve a child’s quality of life.”

Rosemary Black

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Rosemary Black

Rosemary, the mom of seven, was food editor at the New York Daily News for many years and currently writes on health, food, and parenting for various magazines and websites. She is the co-author of six cookbooks, most

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Patients with late-stage knee OA incur high costs for nonoperative treatments before total knee arthroplasty

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In the year before total knee arthroplasty (TKA), patients incur considerable costs for nonoperative treatments and other procedures for osteoarthritis (OA) – raising questions about the value of those procedures, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

The study shows “substantial variation in the type and cost of nonoperative procedures for patients with late-stage knee OA prior to TKA,” according to the report by Eric L. Smith, MD, of New England Baptist Hospital, Boston, and colleagues.

Estimated costs of $2.4 billion over 3 years for nonoperative procedures before TKA

Using nationwide commercial insurance databases, the researchers analyzed claims for nearly 24,500 patients who underwent primary TKA in 2018 and 2019. The study examined the types and costs of nonoperative procedures in the months leading up to TKA.

Average costs for nonoperative procedures in the year before TKA were $1,355 per patient. Knee imaging studies were the most common procedure overall, performed in about 96% of patients. Intra-articular steroid injections were the most frequent treatment procedure, performed in 54%. Bracing was the least common nonoperative treatment, performed in approximately 8% of patients.

Intra-articular injection of hyaluronic acid, excluding professional administration fees, was the most costly procedure: performed in about 13% of patients, it made up 10% of total costs. By comparison, steroid injections were performed in more than half of patients, but accounted to just over 1% of costs. Physical therapy was used in about 27% of patients and accounted for about 17% of costs.

Most patients underwent at least two nonoperative treatments, while more than one-third underwent three or more. Costs increased with time between diagnosis and surgery, exceeding $2,000 in patients with a 12-month duration before undergoing TKA.

Women had higher total costs for nonoperative treatment, with the greatest differences in physical therapy and prescription of nonsteroidal anti-inflammatory drugs. Men had higher costs for opioids. Procedures and costs also varied by region, with the Northeast region having the highest average cost ($1,740).

TKA is a highly effective and cost-efficient treatment for knee OA. The researchers note that decisions about TKA can be “extremely complicated,” involving factors related to patients, providers, and insurers. For example, insurers may require some period of nonoperative treatment before authorizing coverage for TKA. With the national focus on reducing costs while delivering high-value care, the requirement of nonoperative treatment in the months before TKA warrants evaluation.

Extrapolated to the 600,000 TKAs performed each year in the United States, the total costs of nonoperative treatment are estimated at $2.4 billion over a 3-year period and are likely to increase in the future. The authors point out some limitations of their study, mainly related to the use of insurance claims data.

“For patients who eventually undergo TKA, the cost-effectiveness of these nonoperative treatments right before TKA needs to be carefully considered as the health-care system transitions toward a value-based model,” Dr. Smith and coauthors conclude. They also note that some nonoperative treatments – for example, intra-articular steroid or hyaluronic acid injections or bracing – do not have strong evidence of effectiveness. The researchers call for further studies focusing on the benefits of nonoperative treatments at different stages of knee OA.

Source:

Journal reference:

Nin, D.Z., et al. (2022) Costs of Nonoperative Procedures for Knee Osteoarthritis in the Year Prior to Primary Total Knee Arthroplasty. The Journal of Bone and Joint Surgery. doi.org/10.2106/JBJS.21.01415.

Originally Appeared Here

Filed Under: joint replacement, ORTHO NEWS

New laser surface modification process with silver provides antimicrobial defense to titanium orthopedic devices

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Process to create nanostructures on implant surfaces also enhances bone cells’ attachment

WEST LAFAYETTE, Ind. – A patent-pending process developed by Purdue University engineers could improve the quality of life for the more than 6 million people who undergo orthopedic and trauma surgery annually, according to a paper published in Langmuir: The ACS Journal of Fundamental Interface Science.

Infection is a major complication when rods, plates, screws and other devices are embedded into people during procedures like joint replacement surgery and spinal fusion surgery. Most infections occur because the devices’ titanium implant surfaces have poor antibacterial and osteoinductive properties; osteoinduction is the process that prompts bone formation.

Rahim Rahimi, a Purdue University assistant professor in the School of Materials Engineering, has created a process that immobilizes silver onto the implant surfaces of titanium orthopedic devices to improve antibacterial properties and cellular integration. The process can be implemented onto many currently utilized metal implant surfaces.

The antibacterial efficacy of laser-nanotextured titanium surfaces with laser-immobilized silver was tested against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. The surfaces were observed to have efficient and stable antimicrobial properties for more than six days. The laser-nanotextured titanium surfaces also provided a 2.5-fold increase in osseointegration properties as compared to the pristine titanium implant surface.

“The first step of the two-step process creates a hierarchical nanostructure onto the titanium implant surface to enhance the bone cells’ attachment,” Rahimi said. “The second step immobilizes silver with antibacterial properties onto the titanium implant surface.

“The technology allows us to not only immobilize antibacterial silver compounds onto the surface of the titanium implants but also provide a unique surface nanotexturing that allows better settle attachment mineralization.

“These unique characteristics will allow improving implant outcomes, including less risk of infection and fewer complications like device failure.”

Rahimi said the traditional method to address infections caused by implanted orthopedic devices often utilizes antibiotics or other surface modifications that have their own associated complications.

“Long-term antibacterial protection is not possible with these traditional drug coatings because a large portion of the loaded drug is released in a short time,” Rahimi said. “There also is often a mixture of microbes that are found in implant-associated infection; it is essential to choose a bactericidal agent that covers a broad spectrum.”

Rahimi disclosed the innovation to the Purdue Research Foundation Office of Technology Commercialization, which has applied for a patent on the intellectual property. Industry partners seeking to further develop this innovation should contact Patrick Finnerty, pwfinnerty@prf.org, about reference number 2022-RAHI-69768.

Rahimi said the next steps to develop the laser process to texturize and immobilize silver onto orthopedic devices are to implement it onto standard orthopedic fixtures, validate the technology to get approval from the U.S. Food and Drug Administration, and license it to companies working in the orthopedic sector.

Rahimi’s research was funded by Purdue’s School of Materials Engineering.

About Purdue University

Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked in each of the last five years as one of the 10 Most Innovative universities in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery. Committed to hands-on and online, real-world learning, Purdue offers a transformative education to all. Committed to affordability and accessibility, Purdue has frozen tuition and most fees at 2012-13 levels, enabling more students than ever to graduate debt-free. See how Purdue never stops in the persistent pursuit of the next giant leap at https://stories.purdue.edu.

About Purdue Research Foundation Office of Technology Commercialization

The Purdue Research Foundation Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university’s academic activities through commercializing, licensing and protecting Purdue intellectual property. In fiscal year 2021, the office reported 159 deals finalized with 236 technologies signed, 394 disclosures received and 187 issued U.S. patents. The office is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. In 2020, IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Contact otcip@prf.org for more information.

Writer: Steve Martin, sgmartin@prf.org

Source: Rahim Rahimi, rrahimi@purdue.edu


ABSTRACT

Laser-Assisted Nanotexturing and Silver Immobilization on Titanium Implant Surfaces to Enhance Bone Cell Mineralization and Antimicrobial Properties

Vidhya Selvamani, Sachin Kadian, David A. Detwiler, Amin Zareei, Ian Woodhouse, Zhimin Qi, Samuel Peana, Alejandro M. Alcaraz, Haiyan Wang, Rahim Rahimi

Despite the great advancement and wide use of Titanium (Ti) and Ti-based alloys in different orthopedic implants, device-related infections remain the major complication in modern orthopedic and trauma surgery. Most of these infections are often caused by both poor antibacterial and osteoinductive properties of the implant surface. Here, we have demonstrated a facile two-step laser nanotexturing and immobilization of silver onto the titanium implants to improve both cellular integration and antibacterial properties of Ti surfaces. The required threshold laser processing power for effective nanotexturing and osseointegration was systematically determined by the level of osteoblast cells mineralized on the laser nanotextured Ti (LN-Ti) surfaces using a Neodymium-doped yttrium aluminum garnet laser (Nd-YAG, wavelength of 1.06 μm). Laser processing powers above 24 W resulted in the formation of hierarchical nanoporous structures (average pore 190 nm) on the Ti surface with a 2.5-fold increase in osseointegration as compared to the pristine Ti surface. Immobilization of silver nanoparticles onto the LN-Ti surface was conducted by dip coating in an aqueous silver ionic solution and subsequently converted to silver nanoparticles (AgNPs) by using a low power laser-assisted photocatalytic reduction process. Structural and surface morphology analysis via XRD and SEM revealed a uniform distribution of Ag and the formation of an AgTi-alloy interface on the Ti surface. The antibacterial efficacy of the LN-Ti with laser immobilized silver (LN-Ti/LI-Ag) was tested against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. The LN-Ti/LI-Ag surface was observed to have efficient and stable antimicrobial properties for over 6 days. In addition, it was found that the LN-Ti/LI-Ag maintained a cytocompatibility and bone cell mineralization property similar to the LN-Ti surface. The differential toxicity of the LN-Ti/LI-Ag between bacterial and cellular species qualifies this approach as a promising candidate for novel rapid surface modification of biomedical metal implants.

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Novel Imaging Technique Reveals Excellent Biologic Fixation in Cementless Knee Replacement

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Newswise — Cementless knee replacement, an alternative approach to the traditional surgery in which bone cement is used, is gaining interest among orthopedic surgeons. Using a novel MRI technique, researchers at Hospital for Special Surgery (HSS) found that a cementless implant demonstrated excellent biologic fixation, and even improved fixation of implant components in some areas in the joint, compared to the standard cemented implant.

HSS hip and knee surgeon Geoffrey Westrich, MD, and colleagues in the HSS Radiology Department used an advanced imaging technique known as “multi-acquisition variable-resonance image combination selective MRI” to assess fixation in patients who had a cementless knee replacement compared to those whose implant was affixed with bone cement.

“The purpose of our study was to quantify and compare the fixation of uncemented versus cemented knee replacement components,” said Dr. Westrich, lead investigator. “At an average patient follow-up of 16 months, our study demonstrated robust fixation of the cementless knee replacement components, with results comparable to the cemented total knee replacements. And while there was no clinically significant difference regarding overall fixation in the knee, there were some component areas in which cementless fixation appeared to be superior.” The study was published in the October edition of the journal Arthroplasty Today.  

The HSS researchers performed MRIs in 20 patients who had a cementless knee replacement. A matched control group of 20 patients with a cemented knee replacement was also evaluated. The images were reviewed by a fellowship-trained musculoskeletal radiologist specializing in the interpretation of joint replacement MRI, including more than 20 years of experience in assessing bony fixation of knee replacement components.

In a traditional knee replacement, implant components are secured in the joint using bone cement. It’s a tried-and-true technique that has worked well for decades. But eventually, over time, the cement may start to loosen from the bone and/or the implant. This loosening is the leading cause of revision surgery, in which a patient needs a second knee replacement.

“With the cementless prosthesis, the components are press fit into place for biologic fixation, which basically means that the bone will grow into the implant,” explains Dr. Westrich, who believes a well-designed cementless implant will make loosening over time less likely. This could enable a total knee replacement to last much longer, a particular concern for younger patients.

“Overall, traditional knee replacement offers excellent outcomes and longevity,” he says. “However, younger patients generally put more demands on their joint, causing more wear and tear and potential loosening. The cemented knee implant used in a traditional joint replacement usually lasts 15 to 20 years.”

Cementless implants have been used successfully in total hip replacement surgery for many years. It has been much more challenging to develop a cementless prosthesis that would work well in the knee because of its particular anatomy, Dr. Westrich explains.

“Early generation cementless implants had numerous design flaws resulting in loosening and poor survivorship compared to cemented knee replacements,” he says. “More contemporary cementless knee components such as those used in our study utilize highly porous surfaces to promote biologic fixation of the prosthesis. This should improve outcomes.”

Candidates for the cementless procedure are generally patients under age 70 with good bone quality to promote biologic fixation. In addition to younger patients, Dr. Westrich notes that the cementless implant may prove to be a good option for very overweight patients who tend to put more stress on their joint replacement.

“While our study found that early fixation of cementless total knee components are comparable, if not superior, to cemented total knee replacement, further study with a larger number of patients over a lengthier time period is needed to assess long-term durability and fixation.”

Disclosure: Research support received from Stryker Corporation. 

 


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Filed Under: joint replacement, ORTHO NEWS

Preparing for Joint Replacement Surgery

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Contact friends and family for support. You may need help bathing, using the toilet, cooking meals, doing laundry or housework, shopping, going to your doctor’s office, and exercising for several weeks. Contact family members or friends ahead of time to make the necessary arrangements. If you don’t have someone to help you at home, ask your doctor about home caregivers. There are various support networks that can provide emotional support and, in many areas, there are also businesses that offer in-home support.

Get your home ready for your recovery. Store frequently used items such as cleaning supplies, food, remote controls, medications, and reading materials in easy-to-reach locations. Avoid very high or very low shelves as these may require you to use a step stool or kneel.

Plan for meals. Make and freeze meals or stock up on frozen dinners before surgery so that meal preparation is easier and requires less effort. You should plan on making enough meals for at least one week.

Check the safety of your home to prevent falls or tripping. Move long electrical and telephone cords against the wall, remove rugs, and place a non-skid mat in your bathtub. You may want to prepare a bed on the ground level of your home so you can avoid climbing stairs. Have an elevated chair or high-seated chair with arms in every room if possible.

A little time spent getting your home ready before your surgery can make a big difference in your recovery. Some ideas to get started, include:

  • Stock up on toilet paper, shampoo, toothpaste, medications, and other personal items
  • Put a chair in your shower
  • Get a hand-held shower head
  • Get a raised toilet seat
  • Get a shower sponge with a long handle
  • Put handrails in the shower and next to the toilet
  • Install nightlights throughout the house
  • Wash all your towels, linens, and dirty clothes
  • Place loose clothing and pajamas in upper drawers or closets
  • Reachers and grabbers will come in handy
  • To keep your hands free for balance, consider using a walker basket, hip-pouch, small backpack, or an apron with large pockets to hold things you’ll want nearby
  • Rent/buy/borrow plenty of books, movies, music, and puzzles
  • Call your local post office to request that mail be left at your front door instead of in your mailbox

Originally Appeared Here

Filed Under: HIP, joint replacement, KNEE, ORTHO NEWS, ortho news - Google

The Challenge of Knee OA and the Potential of Manual Therapy

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Knee osteoarthritis is a major public health problem that primarily
affects the elderly. Almost 10 percent of the United States population
suffers from symptomatic knee osteoarthritis by the age of 60. In fact,
OA is prevalent worldwide, especially with an increasingly aging
society. It is one of the leading causes of pain and dysfunction in the
joints among the aging population. Despite this, there are no approved
interventions that ameliorate structural progression of this disorder. Continue reading on digital


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