There are several categories of injections for athletes, each with its purpose and benefits. Athletes may benefit from certain types of medical injections, and those will be discussed.
Generally, there are three particular reasons an athlete might require an injection. These are to combat pain, reduce inflammation, and aid in surgical procedures. Injections can also be used in a rehabilitation program for injury maintenance.
In the following, we’ll discuss some of the details about injections used to treat athletes. In addition, we’ll distinguish several types of injections and their uses and benefits.
Types of Injections
Athletes often require injections for some type of treatment. With so many different injuries and problems with pain, certain injections can help pave the way for an athlete to return to the sport they love.
The most common athlete-related injuries requiring injection include bursitis, tendonitis, carpal tunnel syndrome, muscular injuries such as strains and contusions, and more severe injuries such as tendon or ligament tears or ruptures.
Below are the three most common injections that athletes receive for various treatments:
A staple in history for the treatment of muscular trauma and inflammatory injuries in athletes, corticosteroids have been known to many as the superior option of treatment.
Its reputation in the medical literature is profound, such that it has been the most consistent symptomatic relief of pain for so many people with minimal bad side effects.
Corticosteroids do have some potential risks and side effects, and complications, especially when intramuscularly injected. Nevertheless, corticosteroids are a common injective treatment used on athletes regularly, and they have been shown through comprehensive research and systematic reviews to be extremely beneficial both in the short-term and long term.
Corticosteroid injections may also have the benefit of decreasing the overall need for additional steroid use in the future by the athlete.
Local Anesthetic
The use of local anesthetic is highly beneficial for the immediate relief of pain, whether caused by injury or other inflammatory conditions. It also plays a significant role during surgical procedures both at the pre-surgical stage and the postsurgical recovery. More and more surgeons have adopted the use of local anesthetic at the area of surgical incisions at the conclusion of the operation. This significantly improves immediate postoperative pain control.
Like any type of injection to the body, local anesthetic can cause potential adverse reactions such as an allergic reaction. This possibility must be closely monitored post-injection, such that treatment can be administered in the event of an allergic reaction.
Interestingly, in some sports federations, local anesthesia for the sole purpose of pain relief has been banned due to its apparent performance-enhancing benefits.
Ketorolac (Toradol)
Ketorolac, or Toradol, is one of the most common pharmaceutical drugs used in medicine. When injected intramuscularly, Toradol acts as an extremely effective pain reliever without causing the undesirable side effects of some more potent pain medications.
While Toradol has been used regularly for pain control over the years, its uses are still somewhat controversial in certain settings due to its potential ineffectiveness and side effects on certain patients. Toradol can be especially harmful to the kidney in patients who already have kidney damage or have a higher risk of developing kidney damage.
Potential Side Effects
The risks of the most commonly used injections in athletes are generally low, but it’s best to be aware of what these potential effects are.
The following are some of the side effects and complications that can occur when injecting an athlete with a medication such as a steroidal or non-steroidal therapeutic drug:
Infection
Allergic Reaction
Further Weakening of the Tendon Resulting in Rupture
Increase in Pain Rather Than a Decrease
Muscle Atrophy & Weight Gain
Vascular Injury and Bleeding
Nerve Damage
Breast Tissue Development in Men
Infertility
Acne
Elevated Blood Pressure
Syncope (passing out)
These are only some of the potential side effects of injections. In addition, many of these side effects are specific to the type of injection that the athlete receives, as well as the overall health of the athlete at the time of injection. It’s important to understand that not all athletes will be good candidates for medication injections, such as steroids. Therefore, it’s essential that the administration of any injection should be overseen by a medical professional.
Yet, while any medication poses potential risks, the most commonly used injections that have been discussed have been shown to be very safe. It’s best to discuss these issues with your medical doctor to understand these potential side effects better and know your risk.
Final Thoughts
Medical injections used for athletes in sports medicine have proven to be extremely useful. Following particular protocols and safe methodology helps the athlete to be able to continue their sport in the face of obstacles such as pain.
When injections are performed by medical professionals in the organization of a well-designed sports program, the best outcomes for athletes can be achieved.
It’s also important to understand the safety and concerns of injections and their application in your respective sport.
Sports activity is the number one cause of injury in adolescents and young adults. This alone underlines the importance of an effective injury prevention plan, yet, further emphasis is likely needed.
Injuries will undoubtedly have the potential to affect the mental mindset of the athlete. In addition, they also can majorly affect a person’s long-term health and well-being, not to mention the potential implications on the healthcare system, economic environment, and other routine relationships depending on the severity and long-term outlook of rehabilitation.
The importance of having an effective injury prevention protocol, especially as a competitive athlete, is undeniable.
What follows will be a discussion of injury prevention. We’ll begin by outlining what an injury prevention protocol is and how to develop one. We’ll then touch on the most common causes of sports injuries and why a preventative plan is relevant. Lastly, we’ll share the details of some of the most effective injury prevention protocols that you can begin to implement into your physical health regimen.
What is an Injury Prevention Protocol?
An injury prevention protocol is a proactive plan that helps athletes avoid both major and minor injuries and minimize the risk of injury. Fewer overall injuries are the ultimate goal of such a program.
Injury prevention involves a modification of risk factors and focusing on external factors that are within one’s control. For example, an improved diet, increased hydration, and improved sleep may reduce the risk of injury.
Injury protocols are most effective when used in conjunction with individualized strength and conditioning programs. However, it’s also important to know that the use of an injury prevention protocol is based on the athlete’s functional capability, compliance, and attitude toward change. An injury prevention protocol can be implemented in both the short term (hours or days) and long term (weeks or months).
Flexibility is important in injury prevention programs because athletes will not necessarily follow all recommendations, for example, if they feel uncomfortable trying something new or if they don’t believe that a particular strategy actually works.
Injury prevention programs must eventually adapt to the athlete.
Understanding what injuries are most common in your given sport and learning how those injuries are most commonly caused is, at its most basic, how you begin to develop an actionable injury prevention protocol.
The most common sports injuries are:
Strains
Sprains
Fractures
Dislocations & Separations
Ligament Tears
Tendon Ruptures
Tendonitis
Concussions
The most common causes of sports injuries include:
Poor Technique or Form
Being in Poor Physical Health (inflexible, tight, stiff, overweight, immobile)
Lack of Muscular Strength
Lack of Stretching (no warm-up or cool down during activity)
Wearing Improper Gear or Lack of Protective Gear
Impact & Collision
Accidental Fall
While athletes can create and implement a preventative plan on their own, it’s likely more beneficial to consult with a doctor or specialized physician to get their recommendations and take advantage of their professional supervision and monitoring capabilities.
Effective Injury Prevention Protocols
From a medical standpoint, developing and implementing an effective injury prevention protocol requires a multifaceted approach.
Not only do you need to analyze the data surrounding a given injury, but you also need to understand the population and demographic you’re dealing with, the available resources, and the most effective plan to achieve the goal of prevention.
Once you’ve identified the goals and objectives of the prevention protocol, it’s now time to develop the plan and take action. By choosing the most effective protocols discussed below, the athlete will have the best chance to reduce the risk of injury and, at best, prevent it altogether.
Below are the most effective injury prevention protocols for athletes:
Consistent Strength Training Program
Structured Stretching Regimen (Warmup, Cooldown)
Foam Rolling
Proprioceptive Training Program (Balance, Coordination, Agility, Plyometrics, Functional Movement)
Physical Therapy
Manual Therapy
Ensure Proper Technique
Utilizing Protective Equipment
Avoid Overtraining
Proper Rest
Contrast Therapy
It’s important to note that multiple different protocols can be used for any given injury because of so many multitudes of injury types and severity levels.
The good news is that most injury prevention protocols require a similar strategy. By taking a holistic approach to self-care, being proactive with implementation, and remaining consistent with the protocol elements, you give yourself the best chance at success.
Additionally, a sports medicine physician’s specialized input for suitable recommendations, guidance, and supervision is extremely beneficial.
Final Thoughts
As always, the best medicine is prevention. At its most basic, the easiest yet most effective way to prevent sports-related injuries is to stretch, warm up consistently, and cool down.
Recovery is a pillar of sports performance and sports medicine, and without it, injuries are almost guaranteed to occur.
By taking the necessary steps outlined in this article, focusing on stretching, hydration and nutrition, proper technique, and the elimination of overtraining, you give yourself the best chance at reducing the risk of injury.
Football is a high-contact sport made most popular in the United States. Because of the physical nature of the sport, injuries are a common occurrence. In addition, due to the level of physicality involved, certain injuries are more common than others.
What follows will be a discussion of the most common football-related injuries, likely causes of each, and tips on how to prevent them. While not all injuries can be prevented, there are proactive steps that can be taken to ensure that the body is the most prepared for playing football.
Most Common Football-Related Injuries
Hundreds of thousands of young people and adults visit their doctors, medical clinics, and emergency centers for football-related injuries every year.
Additionally, in the first four weeks of the 2020-2021 NFL season, a reported 3,025 injuries were sustained. A typical NFL season spans 18 weeks, not including the postseason time frame.
Lastly, several lawsuits regarding sport-induced concussions in professional football players have reached a point of national news in recent years due to the prevalence and general concern for players’ long-term health.
While football does use protective equipment, it’s still a fast-paced, high-intensity, impact-based sport. Injuries, both minor and traumatic, are going to occur.
Like many sports, there are a variety of causes of different injuries at different severity levels. These include but are not limited to overtraining, lack of recovery, and in-game incidental contact. The most common injuries in football are those of traumatic severity, such as concussions and muscular or ligament tears.
The following are the most common football-related injuries:
Other notable injuries include joint dislocations and separations, hamstring & quadriceps tears, rotator cuff injuries, shin splints, and ulnar collateral ligament (UCL) injury seen commonly in quarterbacks.
Concussions
Concussions are one of the most common injuries in football and contact sports in general. While there is a naive perspective surrounding concussions, especially in sports, they are serious injuries in the category of traumatic brain injury.
Upon impact, the brain shakes back and forth within the skull. The ultimate result of this brain movement within the skull is brain cell damage, which can sometimes be extensive.
According to the NSC, being struck by another person or object is the leading cause of unintentional injury for teens and young adults ages 15 to 24. Further, it’s estimated that 1.6 million to 3.8 million athletes annually suffer a concussion. While not all concussions are related to football, it does happen to be one of the most prevalent injuries seen in football players.
Traumatic Knee Injuries
Traumatic knee injuries include but are not limited to Anterior Cruciate Ligament (ACL), Posterior Cruciate Ligament (PCL), Medial Collateral Ligament (MCL), and meniscus tears. The ACL, for example, is crucial for providing knee stability and strength, a function not only necessary for sport but everyday life.
These career-ending or career-altering ligament injuries are most often the result of rapid changes in motion during play, impact, or faulty movement (i.e., a trip, fall, or twist).
Fractures
Fractures or broken bones are a common occurrence in many sports, football included. The most common locations of a fracture in football are the finger, hand, wrist, and foot.
The causes of a fracture are several. Depending on the location, a fracture can be secondary to overuse, impact, or excessive movement of a given limb.
Tendonitis
The most common form of tendonitis in football is Achilles tendonitis, though it can develop in other regions of the body, such as the elbow. Tendonitis typically results in stiffness, aches, and painful movement. Depending on the severity level, tendonitis can keep a player out of action for some time.
Sometimes tendonitis can develop into a more significant injury like a tendon tear or rupture. For example, a common injury in football is an Achilles rupture.
Sprains, Strains, Aches, & Pains
This category of injury, though less severe, is the most common occurrence in all sports, not just exclusive to football. This is because sport requires such physical demand that the body is put under a lot of stress.
It’s almost inevitable then, depending on the frequency, intensity, and level of play, that these minor impairments will occur over time.
Injuries such as ankle sprains, rotator cuff strains, hamstring strains, and lower back strains are all very common in football. The good news is that these types of minor injuries can often be prevented.
If a carefree attitude is maintained towards preventative behavior, these injuries can lead to a much more severe problem, such as a tear, rupture, or fractured bone.
Injury Prevention Tips for Football Players
Prevention is the best medicine for any disease, condition, illness, or injury. Luckily, many football-related injuries, and sports-related injuries in general, can be prevented.
In fact, According to the U.S. Consumer Product Safety Commission, more than 920,000 under the age of 18 were treated in medical clinics for football-related injuries, most of which could have been prevented. It is also true that unavoidable accidental injuries occur with any sport, even with the best preventative measures.
The following are the most common and effective preventative measures athletes can take to prevent, or at the very least, reduce the risk of such injuries occurring:
Stretching
Adequate Hydration
Avoiding overtraining
Implementing a warm-up and cooldown regimen, both during games, training sessions, practices, and workouts
Performing adaptive strength training exercises
Following prehab protocols (i.e., preventative rehabilitation exercises)
Learning proper tackling techniques
Ensuring that your equipment fits properly
Having regular check-ups with your doctor, physiotherapist, and trainer
The most common ways for injuries to occur outside of accidental happenings or traumatic impacts are a lack of hydration, tightness & stiffness due to lack of stretching, overtraining, and taking part in activity when you’re not properly warmed up.
All of the above are surefire ways to increase your risk of injury. Combatting them is the recipe for prevention.
Final Thoughts
The speed at which one tends to an injury has a direct correlation to the quality and speed of healing. In contrast, ignoring symptoms, especially of injuries such as concussions, can lead to severe complications.
One of the most important things is to seek timely care. If symptoms of an injury persist, additional medical attention should be obtained.
Following preventative tips, as discussed, can significantly reduce the risk of football-related injuries for the athlete.
Total hip replacement is one of the most common non-emergency surgeries. The number of yearly hip replacements performed in the United States is expected to rise to 635,000 by the year 2030 due to the aging population.
Hip replacements are commonly used to treat conditions like arthritis and hip fractures that cause pain and stiffness. The risk of serious complications following a hip replacement is generally low, but all surgeries come with some risk.
Heart attack and other serious cardiovascular complications are possible complications of joint replacement surgeries. The risk of having a heart attack is highest in people with a history of cardiovascular disease and becomes higher with advancing age.
Read on to learn more about the link between hip replacement surgery and heart attacks, including how common heart attacks are after hip surgery, risk factors, and things you can do to prevent them.
A total hip replacement is one of the most successful orthopedic surgeries, with more than a 95 percent survival rate 10 years after the procedure. The majority of hip replacements are performed on people between the ages of 60 to 80.
The single largest cause of death is major adverse cardiac events (MACE), which mostly includes heart attacks. Improvements in surgical techniques and preoperative screening have led to a significant decline in postsurgery death.
The reported 30-day incidence of heart attack ranges from 0.3 to 0.9 percent after total knee or hip replacement.
Why does hip replacement surgery increase the risk of a heart attack?
It’s not exactly clear why your risk of having a heart attack increases after major surgery, but various factors are likely at play.
Some events during surgery may increase stress on your heart. These include:
Inflammation caused during the repair process can increase your blood’s chances of clotting, which can increase your risk of heart problems. Increased heart rate and elevation in blood pressure can put stress on your coronary artery.
With orthopedic surgery, there’s also a risk of developing a fat embolism or cement embolism. That’s when fat or cement from the joint replacement gets released into the bloodstream, causing a blockage or clot. This can cause serious problems with your heart and lungs.
Changes in medications before the surgery, like discontinuing low dose aspirin, may contribute as well.
How common are heart attacks after surgery?
About 3 percent of people undergoing major surgery experience a heart attack during the procedure. Complications become more common with age and in people with a previous history of cardiovascular disease or other risk factors for heart disease.
One in 5 people over 65 or over 45 with a history of cardiovascular disease develop one or more MACE within a year of non-cardiac surgery.
How long is the risk elevated?
Your risk of developing a heart attack remains elevated in the period directly after your surgery, especially in the first week.
In a large 2016 study, researchers found the risk of heart attack became insignificant 1 month after total hip replacement.
Other studies have found that the risk of heart attack remains slightly elevated in the 4 to 6 weeks after hip replacement surgery.
While your risk of a heart attack may decrease after a few weeks, you should still be aware of some other risks. Decreased mobility after hip surgery increases your risk of a blood clot and deep vein thrombosis. This risk will likely persist until you’re active again.
Risk after hip replacement compared to other joint replacements
In a 2021 study, researchers investigated the rates of heart attack among 322,585 people who received spinal fusion or joint replacements. The researchers found that the risk of heart attack was generally higher in people receiving spinal fusion and lower in people receiving knee or hip replacements.
There’s still a limited amount of evidence about how to reduce your chances of a heart attack before surgery. It’s critical to communicate with your doctor ahead of time to evaluate your risk of complications and develop a plan to minimize your chances of developing them.
In evaluating your risk prior to surgery, your doctor will consider several factors, including:
age
overall health and underlying conditions
cardiovascular health
respiratory health
blood pressure
complete blood count
You may undergo several tests as part of the assessment, including:
physical exam
echocardiogram
electrocardiogram
chest X-ray
blood and urine tests
Your doctor may recommend taking medications like statins or beta-blockers leading into your surgery. They may also tell you to reduce or quit smoking and drinking.
Online tools are available to help you assess your risk, but you should always consult with your doctor.
Doctors don’t usually recommend a hip replacement unless your hip is worn to the point it doesn’t respond to physical therapy or steroid injections. It’s almost always an elective surgery. That means it’s not mandatory but performed to improve function and reduce pain.
A promising but developing alternative to a hip replacement for treating osteoarthritis is stem cell injections. These injections contain stem cells that can become cartilage, muscle, or bone. It’s thought that they could help regenerate lost cartilage in your hip.
One small 2018 study found promising results among five people with osteoarthritis. The people in the study experienced an average improvement of 72.4 percent in resting and active pain.
Some conditions that can cause hip pain, like autoimmune arthritis and osteoporosis, are associated with an increased risk of developing a heart attack. But research is yet to show that the conditions are responsible for the higher risk.
Research has found a link between cardiovascular disease and inflammatory forms of arthritis like rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. These conditions cause inflammation throughout your body that may be associated with an increased risk of developing a heart attack.
A 2016 review of studies found that heart disease was 24 percent more common in people with osteoarthritis than in people in the general population.
Studies that look at the prevalence of diseases in large populations have found an observational link between osteoporosis and cardiovascular disease, partly because of shared risk factors like aging.
Researchers have found that the risk of heart attack increases after having a hip replacement. The risk seems to be highest in the month, and particularly in the week, following surgery.
Heart attacks and other surgical complications that affect the heart become more common with advanced age. They’re also more common in people with a history of cardiovascular disease.
It’s important to talk with your doctor before your surgery to evaluate your risk of complications and develop a plan to minimize your risk.
The American College of Rheumatology (ACR)/American Association of Hip and Knee Surgeons (AAHKS) has published guidance regarding perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty.
The American College of Rheumatology (ACR)/American Association of Hip and Knee Surgeons (AAHKS) has published guidance regarding the management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty, with emphasis placed on perioperative use of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The last guideline update was published in 2017.
“Advances in antirheumatic therapy have led to remarkable improvements in treatment and quality of life for people with rheumatic musculoskeletal diseases (RMDs); however, total hip arthroplasty (THA) and total knee arthroplasty (TKA) remain a mainstay of treatment among RMD patients with advanced symptomatic joint damage, most frequently those with inflammatory arthritis (IA), including spondylarthritis (SpA), rheumatoid arthritis (RA), or psoriatic arthritis (PsA), and those with systemic lupus erythematosus (SLE),” investigators stated.
Top Insights:
Patients with RA, PsA, SLE, juvenile idiopathic arthritis (JIA), and ankylosing spondyloarthritis (AS) who are undergoing elective THA or TKA: continuing the usual DMARDs through surgery is conditionally recommended for methotrexate, leflunomide, hydroxychloroquine, sulfasalazine, and/or apremilast.
Patients with RA, PsA, JIA, and AS who are undergoing elective THA or TKA: withholding all biologics prior to surgery and planning surgery after the next dose is conditionally recommended.
Patients with RA, PsA, JIA, and AS who are undergoing THA or TKA: withholding tofacitinib, upadacitinib, and baricitinib for 3 or more days prior to surgery is conditionally recommended.
Patients with SLE who are interested in THA or TKA: continuing the usual dose of mycophenolate mofetil, cyclosporine, mizoribine, azathioprine, mycophenolic acid, or tacrolimus, anifrolumab, and voclosporin is conditionally recommended.
Patients with severe SLE undergoing THA or TKA: planning surgery in the last month of the dosing cycle of rituximab and continuing belimumab treatment is conditionally recommended.
Patients with SLE (not severe) undergoing THA or TKA: withholding the current dose of mizoribine, cyclosporine, azathioprine, mycophenolic acid, mycophenolate mofetil, or tacrolimus 1 week before surgery is conditionally recommended.
Patients with SLE (not severe) undergoing THA or TKA: withholding the usual dose of rituximab and belimumab prior to surgery is conditionally recommended.
Patients with severe SLE undergoing THA or TKA: continuing belimumab and planning surgery in the last month of the dosing cycle of rituximab is conditionally recommended.
Patients with RA, PsA, AS, and SLE who had antirheumatic therapy withheld prior to undergoing THA or TKA: therapy should be restarted once wound begins to heal, there is no significant swelling, erythema, or drainage, sutures and/or staples are out, and there is no nonsurgical site infection. This occurs roughly 2 weeks after surgery and is conditionally recommended.
Patients with RA, AS, PsA, and SLE undergoing THA or TKA receiving GCs: continuing current dose of GCs instead of administering supraphysiologic doses of GCs on the day of surgery is conditionally recommended.
According to data from China’s seventh census in 2020, the 60-year-old population has reached 264 million, accounting for 18.7% of the total population; of which 190 million are 65-year-old, accounting for 13.5% of the total population, and have begun to enter the “aging society”. Concomitantly, the periarticular fragility fracture of the hip, a common serious injury, has significantly increased in incidence.1 Hip fractures are recognized as a major threat to older adults, with nearly one-third of patients dying within a year of a hip fracture, and about 50% of survivors unable to return to their pre-fracture functional status.1,2 Patients with hip fractures experience a variety of complications, including frailty.3 And frailty is a predisposing factor for falls and other adverse events, including organ decline, emergency hospitalization, nursing home admission, and death.4 Moreover, frail patients who are already in poor health will become even frailer due to pain, mobility problems and inability to take care of themselves.5 This creates a bad vicious circle.
Regaining mobility after surgery is a top priority in the treatment of hip fractures in elderly patients. However, the choice of anesthesia for elderly hip fracture surgery remains controversial.6 Previous studies have shown that spinal anesthesia does not provide better outcomes after surgery for elderly patients with hip fractures.7,8 Whereas, there are also many studies support spinal anesthesia as the advantages of shortened hospital stay, higher patient satisfaction, shorter anesthesia recovery time, and reduced postoperative opioid consumption.9–11 In addition, spinal anesthesia has the advantages of fast onset, complete block, and no impact on respiratory function,12 which can be widely used in elderly hip fracture surgery. In fact, with the development of ultrasound-guided intraspinal puncture technology, the success rate of intraspinal puncture including spinal anesthesia has significantly increased,13 which may further improve the satisfaction of spinal anesthesia.
At present, the medication and dosage of spinal anesthesia for elderly patients are basically determined by anesthesiologists based on experience, and the dosage of the medication directly affects the patient’s anesthesia effect, hemodynamics, and further affects the prognosis. In this study, 50% and 95% effective doses of ropivacaine in spinal anesthesia (ED50 and ED95) in elderly patients with hip fracture surgery were determined by a modified sequential design. At the same time, the prediction formula of the individual optimal dose is provided to guide the dose selection of ropivacaine in elderly patients with hip surgery and spinal anesthesia in clinical work.
Materials and Methods
Study Design
This is a prospective, modified up-down sequential allocation study, which was conducted in the Department of Anesthesiology of the First Affiliated Hospital of the University of Science and Technology of China from June 2021 to March 2022, and passed the ethics review of the hospital ethics committee (2021KY113), and completed the registration in the China Clinical Trial Registration Center (ChiCTR2100046982). All study participants read and signed informed consent forms. This trial was conducted in accordance with the Declaration of Helsinki.
Eligibility Criteria
The inclusion criteria included (1) ASA classification II–IV; (2) Age ≥ 65 years old; (3) Elective hip fracture surgery (included femoral neck, femoral head, intertrochanteric or subtrochanteric fractures); (4) Sign the informed consent. Exclusion criteria included (1) Administered sedative and analgesic drugs within 3 hours before surgery; (2) Severe dementia; (3) Have uncontrolled neurological or psychiatric diseases; (4) Severe multiple injuries; (5) Contraindications to spinal anesthesia; (6) Participated in other drug trials within three months.
Anesthesia Procedures
Patients fasted for 8 hours before surgery. After entering the room, a “Venturi” mask with an oxygen flow of 2 L/min was used to inhale oxygen, open the venous access, connect the monitor, and continuously monitor the electrocardiogram (ECG), invasive blood pressure (IBP), pulse oxygen saturation (SpO2) and heart rate (HR). The anesthesia method is combined spinal-epidural anesthesia, the puncture is performed after ultrasound-guided positioning,14 the puncture point is L2-3, 2% lidocaine is selected as the local infiltration anesthesia, and 0.5% ropivacaine diluted with 10% glucose solution was used for spinal anesthesia. The patient is placed in a lateral recumbent position (the affected side is down), and spinal anesthesia is performed first. After the cerebrospinal fluid is confirmed to be smooth, 0.5% ropivacaine is given in about 30 seconds. Then an epidural catheter of 3–5 cm is indwelled in the epidural space. After ropivacaine injection, the lateral decubitus position was maintained for 15min to achieve unilateral block.15 Intraoperatively, additional 1% lidocaine should be added to the epidural space as needed, at the discretion of the anesthesiologist. The epidural catheter was removed after surgery.
Study Interventions
The dose of ropivacaine received by each patient in stage I was determined by a sequential method. Specifically, the initial dose was set at 7.5 mg. When the anesthesia effect of the previous patient was satisfactory, the dose of the next patient was reduced by 0.5 mg; when the anesthesia effect of the previous patient was unsatisfactory, the dose of the next patient was increased by 0.5 mg. In addition, considering the clear effect of height on the dose of spinal anesthesia, the dose should be further corrected by reference to height: for every 10cm increase or decrease in height, the dose should be increased or decreased by 0.5mg.
Definition of Satisfactory Anesthesia: (1) Anesthesia plane (assessed by acupuncture): higher than T10, lower than T6; (2) Pain-free operation within the first hour of surgery.
After the establishment of the optimal dose formula, the validation cohort was included in stage II. Spinal anesthesia was performed using the ropivacaine dose provided by the formula to evaluate the effectiveness of the formula to guide clinical ropivacaine dose selection and the success rate of meeting surgical needs.
Sample Size Calculation
The logistic regression model of this study plans to screen independent variables such as age, gender, height, weight, ASA classification, hemoglobin, white blood cells, red blood cells, and C-reactive protein. The calculation is based on the Events Per Variable principle,16 that is, the sample size is the independent Variable expected to be included multiplied by 10. Furthermore, considering the 20% dropout rate, 114 cases were finally included in the stage I of this study. In stage II, another 30 cases were included to verify the formula. A total of 144 patients.
Statistical Analysis
For numeric variables, the Shapiro-Wilk test was used to verify normality. Normally distributed variables are expressed as the mean (standard deviation), and abnormally distributed variables are expressed using the median (interquartile range). Categorical variables are expressed as numbers (percentages). Independent two-sample t-tests were used to compare normally distributed variables. Abnormally distributed variables were compared using the Mann-Whitney U test. Categorical variables were analyzed using the χ2 test or Fisher’s exact test. Probit regression was used to calculate ED50, ED95 and their 95% confidence interval (CI). Logistic regression was used to screen variables, and odds ratio (OR) was used to describe the variables included in univariate and multivariate regression models. Meanwhile, nomogram is established, and C-index evaluates its predictive ability. For patients who meet satisfactory anesthesia, a multiple linear regression model is used to establish a dose prediction equation. Data were analyzed using SPSS (version 24.0; SPSS Inc., IBM, Chicago, IL, USA). All statistical tests were two-tailed, and a P-value less than 0.05 was defined as statistically significant.
Results
Overall, a total of 180 patients were screened in this study between June 2021 and April 2022. Among them, in stage I, 15 patients refused to participate, 14 patients did not meet the criteria for admission, and 2 patients were unsuccessful in spinal anesthesia; In stage II, 1 patient refused to participate, and 4 patients did not meet the criteria for admission. A total of 144 patients completed the study, 114 in stage I and 30 in stage II. The complete selection flow chart of subjects in this study is shown in Figure 1. Baseline characteristics such as demographics and surgical information are shown in Table 1.
Table 1 Baseline Characteristics
Figure 1 Flow chart of the study.
ED50 (CI) and ED95 (CI)
According to the calculation results of Probit regression, the ED50 and ED95 of ropivacaine for spinal anesthesia of elderly hip fracture were 7.036 mg (95%CI 6.549–7.585 mg) and 8.709 mg (95%CI 7.902–14.275 mg), respectively. Goodness-of-fit test of the model P=0.108 > 0.05. The specific dose and the corresponding number of cases are shown in Table 2.
Table 2 Dose and Corresponding Number of Cases
Variable Filtering and Nomogram
Nine independent variables were included in this study and entered into logistic regression, including age, gender, height, weight, ASA classification, hemoglobin, white blood cells, red blood cells, and C-reactive protein. Group comparisons are made according to whether satisfactory anesthesia is achieved. Comprehensive consideration of univariate analysis results and clinical practice, and finally screen out age, gender, height, and weight into the model. Crude and adjusted OR are shown in Table 3. It should be explained that the OR value failed to reflect the correlation between height and anesthesia effect because the sequential plan was modified by using height in this study.
Table 3 Multivariate Logistic Regression Model
Additionally to that, we visualized the logistic regression model using the nomogram constructed by the factors described above (Figure 2). Using C-index to evaluate the discrimination of the nomogram, C-index=0.847 (95%CI 0.774–0.92), suggesting good prediction accuracy. The nomogram model was internally verified by Bootstrap repeated 1000 times sampling method, and the calibration curve of the prediction model was obtained (Figure 3), which showed that the prediction model was in good consistency with the actual observed results.
Figure 2 Nomogram to predict probability of satisfactory anesthesia.
Figure 3 Calibration curve for nomogram.
Formula for Predicting the Optimal Dose
According to the definition of satisfactory anesthesia in this study, there were 58 patients with appropriate anesthesia plane and satisfactory analgesic effect within the first hour of surgery. Based on this, the multiple linear regression model was used to incorporate age, gender, height and weight into the model as independent variables, and the following formula can be calculated: Dose(mg) = -1.39 + age(year)*0.011 – gender(male = 1; female = 0)*0.249 + height(cm)*0.047 + weight(kg)*0.005
This calculation equation has statistical significance, F=5.691, P=0.001<0.05, indicating that there is a linear correlation between the dependent variable and the independent variable. Correlation coefficient R=0.548, determination coefficient R2=0.3.
Verification of Efficacy and Safety of the Formula
The stage II of this study included 30 patients, and the same anesthesia protocol was implemented as the stage I. The ropivacaine dose was provided by the prediction equation established in stage I. Finally, the anesthesia plane of 1 patient was below T10, 1 patient felt pain during skin incision, and the other 1 patient were satisfied with analgesia at the beginning of the operation, but the duration was less than 1 hour. The anesthesia plane of the 27 patients was suitable and could provide a completely satisfactory anesthesia effect within the first hour of surgery, indicating that the formula had an effective rate of 90%. Namely, this predictive formula can guide clinical ropivacaine dose selection to a considerable extent.
Perioperative Events
The perioperative-related adverse events in this study were mainly hemodynamic changes, including hypertension and hypotension after spinal anesthesia. In stage I, 20 patients had hypotension and 11 patients had hypertension. The cases of hypotension and hypertension in stage II were both 3. It should be noted that there was no significant and uncorrectable hypotension during the trial. The occurrence of hypertension may be related to the nervousness of patients during the operation. The number of patients with inappropriate anesthesia plane or insufficient analgesia within the first hour of surgery according to the definition of satisfactory anesthesia is shown in Table 4.
Table 4 Perioperative Events
In stage I, after surgery, 99 patients (86.84%) were directly transferred to the ward, 9 (7.89%) were transferred to PACU, and 6 (5.26%) were transferred to ICU. In the stage II, after surgery, 28 patients (93.33%) were directly transferred to the ward, 2 (6.67%) were transferred to PACU, and none were transferred to the ICU.
Discussion
In this prospective, modified up-down sequential allocation study, we first calculated the ED50 and ED95 of ropivacaine for spinal anesthesia in the elderly with hip fractures, with specific values of 7.036 mg and 8.709 mg, respectively. After that, by screening the factors affecting the anesthetic effect, a more intuitive nomogram for predicting satisfactory anesthesia was established. The calculation formula for predicting the optimal dose of ropivacaine is then provided directly through the multiple linear regression model, and the factors included in the regression model included age, gender, height, and weight. After that, in stage II, the ropivacaine dose provided by the formula was used for spinal anesthesia, and the success rate was 90%. To our knowledge, this study is the first to provide a formula for calculating the optimal dose of ropivacaine for elderly hip fracture surgery.
Mei et al showed that the ED50 and ED95 of hyperbaric ropivacaine for cesarean section were 11mg and 15mg,17 and the sequential study of Lv et al showed that the ED50 of hyperbaric ropivacaine for cesarean section was 8.29mg.18 Practically, due to high abdominal pressure and distended intraspinal veins, the drug dose required for spinal anesthesia for puerperae is lower than that of non-puerperae women. However, the dose in the above study was still significantly higher than the ED50 and ED95 of 7.036 mg and 8.709 mg in this study. We believe that the main reason for the difference is that, in this study, after ropivacaine was injected into the subarachnoid space, the lateral decubitus position was maintained for 15 minutes, which enabled the realization of Unilateral spinal anesthesia. Secondly, the puncture point of L2-3 can also reduce the dosage of anesthetic drugs. Advanced age may be another reason.
There are many factors influencing the effect of spinal anesthesia. Age, height, weight, body position, drug specific gravity, liquid volume, concentration, injection speed, puncture point, patient position, abdominal circumference, and even lumbosacral cerebrospinal fluid volume can all affect the anesthesia block plane.19–24 In this trial, we controlled the controllable factors as much as possible, and the patient’s body position, puncture point, drug specific gravity, concentration, and injection speed were all kept consistent. On this basis, statistical analysis first found that age was a statistically significant influencing factor. Moreover, height, as part of the modified sequential protocol, also indisputably influenced the trial results. Furthermore, considering that elderly patients have large differences in body weight, and gender may affect patients’ perception of pain. Finally, four factors of age, gender, height, and weight are included in the statistical model. Then, we used these four factors to build a nomogram in order to more intuitively discover the impact of the inclusion factors on the probability of satisfactory anesthesia.
The dose of spinal anesthesia drugs significantly affect the anesthesia effect, including the analgesia plane, hemodynamics, and even long-term prognosis.25 The physiological homeostasis of the elderly is significantly more likely to be affected due to their weak vascular elasticity and poor nutritional status. At present, there is no unified plan for dose selection for elderly hip fracture surgery. Our study provides a formula for the dose selection of ropivacaine for spinal anesthesia, and the effective rate is 90%, which has high practical value. It is worth mentioning that the definition of satisfactory anesthesia in this study is that there is no pain within the first hour of the operation. Although the duration is not long, it can fully ensure that the dose is not excessive and the hemodynamics is stable. Furthermore, considering that surgically destructive stimulation, including skin incision and reamed intramedullary, occurs mainly within the first hour, the dose provided by the formula can be considered the lowest and optimal option.
Previous literature has suggested that appropriate spinal anesthesia has better perioperative hemodynamic stability than general anesthesia, and the need for intraoperative vasopressors is also significantly reduced.26 In elderly patients, the incidence of blood pressure drop after spinal anesthesia can be as high as 75%.27 In contrast, in this study, the incidence of hypotension after spinal anesthesia was only 20% in stage I and 10% in stage II. The main reason for this advantage is that unilateral anesthesia was well implemented in this trial, and only unilateral sympathetic nerves were blocked as much as possible. Moreover, the definition of satisfactory anesthesia in this study is relatively loose, and it is not mandatory that a single dose can meet the needs of the entire operation, resulting in a significant reduction in drug dosage. In addition to hemodynamics, the postoperative destination is also worthy of attention. In this study, the proportion of patients directly transferred to the general ward after surgery was as high as 86.84% and 93.33% respectively in the two trial stages, which may bring significant improvement in patient satisfaction and also help alleviate the shortage of anesthesia medical resources in China. It is worth noting that in stage II, when dose selection was guided by the calculation formula, the number of patients admitted to the ICU was 0, while the literature reported that the ICU transfer rate was about 7% in the elderly after surgery for hip fracture under general anesthesia.28 Given that the median age of patients in this study was as high as 80 years, the prognostic advantage of reducing the rate of ICU admission may have been greater than expected.
In addition to the above, there are some peculiarities in this study in terms of the trial protocol. First, the puncture site for spinal anesthesia was L2-3, considering that previous studies have provided some dosage options for L3-4.25,29 And due to factors such as hyperosteogenesis and ligament calcification in elderly patients,30 there are always some cases of failed puncture in the L3-4 space. At that time, L2-3 is a safe additional choice. Moreover, ultrasound-guided positioning can ensure the accuracy of puncture point. Second, we chose hyperbaric liquid in this trial, based on the fact that hyperbaric liquid can achieve anesthesia block effect more quickly than hypobaric and isobaric,31,32 and is more popular among surgeons.
There are also some limitations worth discussing in this study. First, this study did not set up a control group, but only a dose-finding test of ropivacaine in a single group. It is still necessary to compare with other commonly used drugs for spinal anesthesia such as bupivacaine in the future to determine the best choice of drug types. Second, this study paid relatively little attention to the prognosis of patients, mainly because we focused on the evaluation of intraoperative anesthesia effect, and the comparison of prognosis also needed to set up a control group. Last but not least, the calculation of the sample size of this study is based on the minimum sample size of logistic regression, which does not mean that the sample size is sufficient. In particular, the efficacy and safety of the calculation formula need to be confirmed by clinical trials with larger samples, or even randomized controlled trials.
At present, the debate on the pros and cons of different anesthesia options for elderly hip fractures is still ongoing. This study starts with spinal anesthesia, focuses on the dose selection of ropivacaine, and gives a specific calculation formula, which meets the requirements of precise anesthesia. Subsequent research can further compare the different densities of drugs and different types of drugs in spinal anesthesia, and screen the optimal general anesthesia scheme at the same time. Finally, comparing the optimal spinal anesthesia scheme with the optimal general anesthesia scheme is the future direction to explore the choice of anesthesia for elderly hip fracture surgery.
Conclusion
In conclusion, this study explored the optimal dose of ropivacaine for spinal anesthesia in elderly hip surgery. The ED50 and ED95 were 7.036 mg and 8.709 mg respectively. A nomogram for predicting satisfactory anesthesia was established with high accuracy. In addition, this study also provides a dose prediction equation of ropivacaine, which has high efficacy and safety, and can guide anesthesiologists in the choice of dose in clinical practice.
Data Sharing Statement
Six months after the main results are published, the individual participant data of this research report can be accessed with the permission of the corresponding authors. The study protocol, statistical analysis plan, and clinical study report will also be available.
Acknowledgments
Appreciate for the support from the Orthopedist and nursing teams of the First Affiliated Hospital of USTC.
Author contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Funding
This research was not funded by any source in the public, commercial, or nonprofit sectors.
Disclosure
The authors report no conflicts of interest in this work.
References
1. Bellelli G, Morandi A, Trabucchi M., et al. Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons. Intern Emerg Med. 2018;13(1):113–121. doi:10.1007/s11739-017-1705-x
2. Bellelli G, Mazzola P, Corsi M, et al. The combined effect of ADL impairment and delay in time from fracture to surgery on 12-month mortality: an observational study in orthogeriatric patients. J Am Med Dir Assoc. 2012;13(7):664.e9–664.e14. doi:10.1016/j.jamda.2012.06.007
3. Inoue T, Maeda K, Nagano A, et al. Undernutrition, sarcopenia, and frailty in fragility hip fracture: advanced strategies for improving clinical outcomes. Nutrients. 2020;12(12):3743. doi:10.3390/nu12123743
4. Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet. 2019;394(10206):1365–1375. doi:10.1016/S0140-6736(19)31786-6
5. Bergström U, Jonsson H, Gustafson Y, et al. The Hip fracture incidence curve is shifting to the right. Acta Orthop. 2009;80(5):520–524. doi:10.3109/17453670903278282
6. Griffiths R, Babu S, Dixon P, et al. Guideline for the management of hip fractures 2020: guideline by the association of anaesthetists. Anaesthesia. 2021;76(2):225–237. doi:10.1111/anae.15291
7. Du YT, Li YW, Zhao BJ, et al; Peking University Clinical Research Program Study Group. Long-term survival after combined epidural-general anesthesia or general anesthesia alone: follow-up of a randomized trial. Anesthesiology. 2021;135(2):233–245. doi:10.1097/ALN.0000000000003835
8. Kowark A, Adam C, Ahrens J, et al.; iHOPE study group. Improve Hip fracture outcome in the elderly patient (iHOPE): a study protocol for a pragmatic, multicentre randomised controlled trial to test the efficacy of spinal versus general anaesthesia. BMJ Open. 2018;8(10):e023609. doi:10.1136/bmjopen-2018-023609
9. Neuman MD, Rosenbaum PR, Ludwig JM, Zubizarreta JR, Silber JH. Anesthesia technique, mortality, and length of stay after Hip fracture surgery. JAMA. 2014;311(24):2508–2517. doi:10.1001/jama.2014.6499
10. Capdevila X, Aveline C, Delaunay L, et al. Factors determining the choice of spinal versus general anesthesia in patients undergoing ambulatory surgery: results of a multicenter observational study. Adv Ther. 2020;37(1):527–540. doi:10.1007/s12325-019-01171-6
11. Turner EHG, Whalen CJ, Beilfuss MA, Hetzel SJ, Schroeder KM, Spiker AM. Neuraxial anesthesia is associated with decreased pain scores and post-anesthesia care unit opioid requirement compared with general anesthesia in hip arthroscopy. Arthroscopy. 2021;37(1):139–146. doi:10.1016/j.arthro.2020.08.032
12. Stewart J, Gasanova I, Joshi GP. Spinal anesthesia for ambulatory surgery: current controversies and concerns. Curr Opin Anaesthesiol. 2020;33(6):746–752. doi:10.1097/ACO.0000000000000924
13. Chin KJ, Perlas A, Chan V, Brown-Shreves D, Koshkin A, Vaishnav V. Ultrasound imaging facilitates spinal anesthesia in adults with difficult surface anatomic landmarks. Anesthesiology. 2011;115(1):94–101. doi:10.1097/ALN.0b013e31821a8ad4
14. Chen L, Huang J, Zhang Y, et al. Real-time ultrasound-guided versus ultrasound-assisted spinal anesthesia in elderly patients with hip fractures: a randomized controlled trial. Anesth Analg. 2022;134(2):400–409. doi:10.1213/ANE.0000000000005778
15. Fanelli G, Borghi B, Casati A, Bertini L, Montebugnoli M, Torri G. Unilateral bupivacaine spinal anesthesia for outpatient knee arthroscopy. Italian Study Group on Unilateral Spinal Anesthesia. Can J Anaesth. 2000;47(8):746–751. doi:10.1007/BF03019476
16. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49(12):1373–1379. doi:10.1016/S0895-4356(96)00236-3
17. Mei Z, Ngan Kee WD, Sheng ZM, et al. Comparative dose-response study of hyperbaric ropivacaine for spinal anesthesia for cesarean delivery in singleton versus twin pregnancies. J Clin Anesth. 2020;67:110068. doi:10.1016/j.jclinane.2020.110068
18. Lv M, Zhang P, Wang Z. ED50 of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study. J Pain Res. 2018;11:2791–2796. doi:10.2147/JPR.S174176
19. Chen M, Chen C, Ke Q. The effect of age on the median effective dose (ED50) of intrathecally administered plain bupivacaine for motor block. Anesth Analg. 2014;118(4):863–868. doi:10.1213/ANE.0000000000000147
20. Harten JM, Boyne I, Hannah P, Varveris D, Brown A. Effects of a height and weight adjusted dose of local anaesthetic for spinal anaesthesia for elective Caesarean section. Anaesthesia. 2005;60(4):348–353. doi:10.1111/j.1365-2044.2005.04113.x
21. Fu F, Xiao F, Chen W, et al. A randomised double-blind dose-response study of weight-adjusted infusions of norepinephrine for preventing hypotension during combined spinal-epidural anaesthesia for Caesarean delivery. Br J Anaesth. 2020;124(3):e108–e114. doi:10.1016/j.bja.2019.12.019
22. Wei CN, Zhang YF, Xia F, Wang LZ, Zhou QH. Abdominal girth, vertebral column length and spread of intrathecal hyperbaric bupivacaine in the term parturient. Int J Obstet Anesth. 2017;31:63–67. doi:10.1016/j.ijoa.2017.02.002
24. Higuchi H, Hirata J, Adachi Y, Kazama T. Influence of lumbosacral cerebrospinal fluid density, velocity, and volume on extent and duration of plain bupivacaine spinal anesthesia. Anesthesiology. 2004;100(1):106–114. doi:10.1097/00000542-200401000-00019
25. Lilot M, Meuret P, Bouvet L, et al. Hypobaric spinal anesthesia with ropivacaine plus sufentanil for traumatic femoral neck surgery in the elderly: a dose-response study. Anesth Analg. 2013;117(1):259–264. doi:10.1213/ANE.0b013e31828f29f8
26. Finsterwald M, Muster M, Farshad M, Saporito A, Brada M, Aguirre JA. Spinal versus general anesthesia for lumbar spine surgery in high risk patients: perioperative hemodynamic stability, complications and costs. J Clin Anesth. 2018;46:3–7. doi:10.1016/j.jclinane.2018.01.004
27. Graves CL, Underwood PS, Klein RL, Kim YI. Intravenous fluid administration as therapy for hypotension secondary to spinal anesthesia. Anesth Analg. 1968;47(5):548–556. doi:10.1213/00000539-196809000-00018
28. Gonçalves TJM, Gonçalves SE, Nava N, et al. Perioperative immunonutrition in elderly patients undergoing total hip and knee arthroplasty: impact on postoperative outcomes. JPEN J Parenter Enteral Nutr. 2021;45(7):1559–1566. doi:10.1002/jpen.2028
29. Wang W, Li Y, Sun A, Yu H, Dong J, Xu H. Determination of the median effective dose (ED50) of bupivacaine and ropivacaine unilateral spinal anesthesia: prospective, double blinded, randomized dose-response trial. Anaesthesist. 2017;66(12):936–943. doi:10.1007/s00101-017-0370-9
30. Tang Z, Zhang C, Xu Z, Jin F, Liang D. Observation of single spinal anesthesia by 25G needle puncture through a lateral crypt for Hip surgery in elderly patients. Medicine. 2019;98(27):e16334. doi:10.1097/MD.0000000000016334
31. Uppal V, Retter S, Shanthanna H, Prabhakar C, McKeen DM. Hyperbaric versus isobaric bupivacaine for spinal anesthesia: systematic review and meta-analysis for adult patients undergoing noncesarean delivery surgery. Anesth Analg. 2017;125(5):1627–1637. doi:10.1213/ANE.0000000000002254
32. Cantürk M, Kılcı O, Ornek D, Ozdogan L, Pala Y, Sen O. Ropivacaine for unilateral spinal anesthesia; hyperbaric or hypobaric? Rev Bras Anestesiol. 2012;62(3):298–311. doi:10.1016/S0034-7094(12)70131-9
LISBON, Portugal ― Screening for Staphylococcus aureus, decolonization, and use of teicoplanin for surgical antimicrobial prophylaxis among patients with methicillin-resistant S aureus (MRSA) lowered the number of prosthetic joint infections in elderly patients undergoing surgery for fracture of the femur.
The findings were presented here as a poster at the 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) 2022, which was one of the few awarded the accolade of “top-rated poster.”
“We actually found that with our intervention, all prosthetic joint infections decreased, not just the Staphylococcus aureus but those due to MRSA, too,” said Natividad Benito, MD, an infectious diseases specialist at Hospital de la Santa Creu i Sant Pau in Barcelona, Spain, in an interview with Medscape Medical News. “We’re pleased with these results because prosthetic joint infections present such a complicated situation for patients and surgeons. This is also a relatively easy intervention to use, and with time, even the PCR [polymerase chain reaction] technology will become cheaper. Now, in our hospital, prosthetic joint infections are rare.”
At the Hospital de la Santa Creu i Sant Pau, around 200 hip hemiarthroplasties are performed per year. Preceding the intervention, the hospital recorded 11 prosthetic joint infections, with up to five infections due to S aureus and up to four due to MRSA.
The intervention was introduced in 2016. After 2 years, there were no cases of prosthetic joint infections due to S aureus; in 2018 there, was one case of prosthetic joint infection due to MRSA. In 2019, there was one case of prosthetic joint infection, but it was due neither to S aureus nor MRSA. In 2020 and 2021, there was one infection each year that was due to MRSA.
Jesús Rodríguez Baño, MD,head of the Infectious Diseases Division, Hospital Universitario Virgen Macarena at the University of Seville, Spain, who was not involved in the study, explained that for patients with hip fracture, “the time frame in which colonization can be studied is too short using traditional methods. Prosthetic joint infections in this population have a devastating effect, with not negligible mortality and very important morbidity and healthcare costs.”
Referring to the significant reduction in the rate of S aureus prosthetic joint infections in the postintervention period, Rodríguez Baño told Medscape Medical News, “The results are sound, and the important reduction in infection risk invites for the development of a multicenter, randomized trial to confirm these interesting results.
“The authors are commended for measuring the impact of applying a well-justified preventive protocol,” RodríguezBaño added. However, the study has some limitations: “It was performed in one center, it was not randomized, and control for potential confounders is needed.”
Decolonization in an Emergency Femur Fracture
This study addressed a particular need in residents of Spain’s long-term care facilities. In 2016, the prevalence of MRSA was high.
Roughly one third of the general population carry S aureus in their nose. In care homes, the rate of MRSA is higher than in the general population, at around 30% of those with S aureus. In Spain, recommendations for patients undergoing elective total joint arthroplasty advise S aureus decolonization — which can take 5 days — to prevent surgical site infections.
“The problem with the elderly population is not only have they a higher incidence of MRSA but that the surgical prophylaxis is inadequate for MRSA,” Benito pointed out.
Many patients in long-term care facilities are elderly and frail and are at greater risk of fracture. Unlike elective hip surgery, in which patients are asked to undergo decolonization over the 5 days prior to their operation, with emergent femur fractures, there is insufficient time for such preparation. “These patients with femur fractures need surgery as soon as possible,” said Benito.
No studies have been conducted to determine the best way to minimize infection risk from S aureus and MRSA for patients undergoing emergency hip hemiarthroplasty surgery to treat femoral fractures.
In the current study, Benito and her co-authors assessed whether a bundle of measures — including rapid detection of S aureus nasal carriage by PCR upon arrival in the emergency setting, followed by decolonization of carriers using a topical treatment in the nose and a prescription of surgical antimicrobial prophylaxis (adapted antibiotic prophylaxis for MRSA) — reduces the incidence of prosthetic joint infections after surgery.
The quasi-experimental single-center study included patients admitted to the emergency department at Hospital de la Santa Creu i Sant Pau. The PCR was rapid, with a turnaround of just 1.5 hours. Decolonization of S aureus carriers was carried out using nasal mupirocin and chlorhexidine gluconate bathing, which was started immediately. It was used for a total of 5 days and was usually continued throughout and after surgery.
Patients carrying MRSA received teicoplanin as optimal surgical antimicrobial prophylaxis instead of cefazolin. The intervention did not interfere with the timing of surgery. The study’s principal outcomes were overall incidence of prosthetic joint infections and the incidence of those specifically caused by S aureus and MRSA.
The researchers compared findings regarding these outcomes over 5 consecutive years of the intervention to outcomes during 4 consecutive years prior to the intervention, which started in 2016.
In 2016–2020, from 22% to 31% of the overall number of patients requiring hip hemiarthroplasty were referred from long-term care facilities. From 25% to 29% of these patients tested positive for S aureus on PCR, and of these, 33% to 64% had MRSA.
There were 772 surgical procedures from 2012–2015 and 786 from 2017–2020.
Prior to the intervention, over the years 2012–2014, S aureus caused 36% to 50% of prosthetic joint infections; 25% to 100% of the S aureus infections were MRSA. This decreased significantly after the intervention.
In 2016–2020, there was an average of 14 prosthetic joint infections (1.5%), compared to 36 (4.7%) in 2012–2015 (P < .001). Similarly, the incidence of prosthetic joint infections due to S aureus dropped to 0.3% from 1.8% (P < .002). The incidence of MRSA prosthetic joint infections was 0.3% for 2016–2020, vs 1.2% for 2012–2015 (P = .012).
The years 2018, 2020, and 2021 each saw one case of infection due to MRSA. They were most likely due to “the intervention not being performed properly in all cases,” said Benito.
A prosthetic joint infection is very serious for the patient. “It means reoperating, because antibiotics are not enough to clear the infection. The biofilm and pus of the infection need to be cleaned out, a new prosthesis is needed, after which more antibiotics are needed for around 2 months, which can be hard to tolerate, and even then, the infection might not be eradicated,” explained Benito. “Many of these people are old and frail, and mortality can be significant. Getting a prosthetic joint infection is catastrophic for these patients.”
32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) 2022: Abstract 02516.
Benitos and Rodríguez-Baño have disclosed no relevant financial relationships.
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A randomized controlled trial (RCT) comparing spinal versus general anesthesia for hip surgery found that spinal anesthesia was associated with worse pain immediately after surgery and higher rates of pain reliever prescriptions at 60 days. However, differences in pain, satisfaction, or mental status between the two interventions seemed to diminish at 60, 180, or 365 days after surgery. The findings are published in Annals of Internal Medicine.
More than 250,000 older adults experience a hip fracture every year and nearly all are repaired through surgery. Patient recovery of ambulation and survival at 60 days, delirium, and hospital length of stay are similar whether patients have spinal or general anesthesia during surgery. Not much is known about which type of anesthesia demonstrates better outcomes, though previous studies suggest that patients may have less pain in the first few hours after hip fracture surgery with spinal anesthesia.
Researchers from the University of Pennsylvania Perelman School of Medicine conducted a preplanned secondary analysis of a RCT comparing spinal versus general anesthesia in 1,600 patients aged 50 years or older who were having hip fracture surgery. Trial participants were randomly assigned to general or spinal anesthesia and the researchers collected data on pain on days 1 to 3 after surgery. Pain and use of prescription pain relievers, mental status, and patient satisfaction were assessed at 60, 180, and 365 days after surgery. They authors found that patients who received spinal anesthesia reported worse pain in the 24 hours after surgery but reported similar pain at all other time points. The authors also found that 25 percent of patients in the spinal anesthesia group were using prescription pain relievers at 60 days compared to 18.8 percent of patients in the general anesthesia group. However, the authors note that they did not find differences in pain, satisfaction, or mental status at 60, 180, or 365 days.
In an accompanying editorial, authors from Harvard Medical School argue that this study challenges a dominant narrative about the risks and outcomes of general anesthesia in older adults. The authors also add that this study highlights that surgical repair of hip fractures in older adults carries the risk for severe postoperative pain, regardless of whether the surgery is done with regional or general anesthesia. They suggest that future research investigate the differences in reported pain as presented in this study and the RAGA (Regional Anesthesia vs General Anesthesia) trial but note that participants in the RAGA trial may have experienced more extensive postoperative care.
Gymnastics is a sport that requires a lot of flexibility, strength, and stamina. Over time, gymnasts’ bodies can become injured because of the strain caused by gymnastics. Gymnasts often get tendonitis, which is an inflammation of the tendons. Overuse can cause this inflammation, as well as a few other common gymnastics injuries.
Less common but more serious injuries include neck and back problems, such as spondylolysis and spondylolisthesis. These injuries are much more serious than the ones mentioned before, and if not treated right away can cause a lot of pain and discomfort.
Treatment for these injuries varies depending on the injury itself, but usually includes resting or even surgery in some cases. Prevention methods include stretching and warming up before you start your daily routine or practice.
Gymnasts are susceptible to strains and sprains, because they use their bodies in unusual ways. However, there are ways to prevent both types of injuries from happening: proper stretching techniques and warming up before each practice or event.
Injury prevention is the standard to achieve in this sport. While all injuries can’t be prevented, the effort to prevent as many injuries as possible is key to improving longevity within the sport. Unfortunately, many unpredictable accidents do occur in this sport.
By prioritizing physical health, you provide your bones, muscles, joints, ligaments, and tendons with the most substantial environment to perform yet remain uninjured.
Prioritizing physical health requires proactive actions, consistent exercise implementation, and rehabilitative strategies before an injury occurs. The following are the most common and effective preventative measures for gymnasts to reduce the risk of injury:
Avoid loose clothing and wear proper gymnast attire
Wear protective gear during training (i.e., hand grips, chalk, heel pads, wrist wraps, braces)
Rest and recover
Use spotters
Ensure the basic equipment safe and intact
Summary
Gymnastic injuries often don’t require surgery, but they usually require some medical attention. When injuries occur, no matter the severity, it’s important to seek treatment immediately.
Ignoring symptoms prolongs healing, increases suffering, and can result in more significant problems down the road.
Following preventive techniques can greatly reduce the risk of injury.
HARTFORD, CT, July 23, 2022 /24-7PressRelease/ — It is often said that a knee is simply not a knee post-surgery. As is the case with so many aspects of our lives and bodies that we take for granted. We scarcely realize how much pressure a joint like the knee must endure to keep us moving smoothly and pain-free. Of course, this is until something goes wrong and we need surgery to correct it.
While knee surgeries are sometimes the best option, they have come a long way. Improvements have been primarily due to the changes in medical knowledge and available technologies.
How ROM Technologies is Changing the Game
As stated prior, technology has done wonders to improve the results we experience from undergoing knee surgery. Much of this is due to changes in post-surgery knee recovery technology. ROMTech is a leading organization in pre-op and post-op knee surgery recovery.
Knee replacement is the most popular surgical option. In the past, this would leave recipients with stiff knees that would not help them move or function as efficiently as they desired. Today, the opposite is true.
Today, athletes can undergo knee replacement surgery and, with strategic rehabilitative work, find that they can work their way back to peak capacity. Thanks to leading medical technology organizations, having a knee rehabilitation resource helps ensure that patients can recover as quickly and efficiently as possible with smooth, pain free movement.
Knee replacement surgery no longer means that a sporting career has to end or that daily life has to be significantly hampered. Thanks to ROMTech’s work in producing high-quality joint replacement material, their work is not only limited to knees.
ROM Technologies PortableConnect actually used in both knee and hip patients rehabilitation as well. This makes sense, as a debilitatingly injured or arthritic hip can impact the knees negatively and vice versa. It makes sense that these key features of the lower extremities are considered in tandem.
How to Get Started Working with ROMTech
Since their PortableConnect device enables knee and hip recovery it is easy to see what their focus is on, improving quality of life. Sometimes people with knee and hip issues may be concerned with having to do a procedure.
However, the advancements in ROM Technologies help ensure that higher-quality replacements help reduce the likelihood of the same. As such, they encourage anyone who may need replacement surgery (irrespective of age or even profession) to have it done sooner rather than later.
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